ethyl 6-amino-4-(3-methoxyphenyl)-5-cyano-1,4-dihydropyrano[2,3-]pyrazole-3-carboxylate | 1620887-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: ethyl 6-amino-4-(3-methoxyphenyl)-5-cyano-1,4-dihydropyrano[2,3-]pyrazole-3-carboxylate
• CAS: 1620887-45-7
• 化学式: C₁₇H₁₆N₄O₄
• 分子量: 340.338
• InChiKey: RTHKBFXUSQQFTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  123.25
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  3-甲氧基苯甲醛 在 一水合肼 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 2.5h， 生成 ethyl 6-amino-4-(3-methoxyphenyl)-5-cyano-1,4-dihydropyrano[2,3-]pyrazole-3-carboxylate
  参考文献：
  名称：

  A novel four-component synthesis of ethyl 6-amino-4-aryl-5-cyano-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates

  摘要：

  Ethyl 6-amino-4-aryl-5-cyano-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates were synthesized via a four-component reaction of the sodium salt of diethyloxaloacetate, an aromatic aldehyde, hydrazine hydrate, and malononitrile. The products were obtained in moderate to high yields. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.06.077

文献信息

• New synthesis of ethyl 6-amino-4-aryl-5-cyano-1,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates
  作者：V. L. Gein、T. M. Zamaraeva、I. V. Kozulina

  DOI：10.1134/s1070428014050121

  日期：2014.5

  Ethyl 6-amino-4-aryl-5-cyano-1,4-dihydropyrano[2,3-c]pyrazol-3-carboxylates were synthesized by a reaction of diethyloxalacetate sodium salt with aromatic aldehyde, hydrazine hydrate, and malononitrile in the presence of acetic acid.