1-(5-Chloro-2-methylphenyl)-2-ethylsulfanylimidazole-4,5-dione | 302840-81-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(5-Chloro-2-methylphenyl)-2-ethylsulfanylimidazole-4,5-dione
• CAS: 302840-81-9
• 化学式: C₁₂H₁₁ClN₂O₂S
• 分子量: 282.751
• InChiKey: XXLPNNPGDOREKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  75
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(5-Chloro-2-methylphenyl)-2-ethylsulfanylimidazole-4,5-dione 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 1-(5-chloro-2-methylphenyl)-2-(ethyl sulfanyl)imidazoline-4,5-dione
  参考文献：
  名称：

  Effects of 2-(substituted-sulfanyl)-3,5-dihydro-imidazole-4-one and 2-(substituted-sulfanyl)-1H-imidazole-4,5-dione derivatives on serum HDL-cholesterol

  摘要：

  A series of 2-substituted sulfanyl-3,5-dihydro-imidazole-4-one and 2-substituted sulfanyl-1H-imidazole-4,5-diones was prepared and shown to increase high density lipoprotein cholesterol over other lipid fractions. Compound If showed efficacy in additional animal models. The major metabolite of If was isolated and its synthesis is reported. The effects of the metabolite on the lipid profile in rats were investigated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00338-3
• 作为产物：
  描述：

  5-氯-2-甲基异硫氰酸苯酯 在 ammonium hydroxide 作用下， 以 乙醇 、 氯仿 为溶剂， 生成 1-(5-Chloro-2-methylphenyl)-2-ethylsulfanylimidazole-4,5-dione
  参考文献：
  名称：

  Effects of 2-(substituted-sulfanyl)-3,5-dihydro-imidazole-4-one and 2-(substituted-sulfanyl)-1H-imidazole-4,5-dione derivatives on serum HDL-cholesterol

  摘要：

  A series of 2-substituted sulfanyl-3,5-dihydro-imidazole-4-one and 2-substituted sulfanyl-1H-imidazole-4,5-diones was prepared and shown to increase high density lipoprotein cholesterol over other lipid fractions. Compound If showed efficacy in additional animal models. The major metabolite of If was isolated and its synthesis is reported. The effects of the metabolite on the lipid profile in rats were investigated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00338-3

文献信息

• Effects of 2-(substituted-sulfanyl)-3,5-dihydro-imidazole-4-one and 2-(substituted-sulfanyl)-1H-imidazole-4,5-dione derivatives on serum HDL-cholesterol
  作者：Hassan Elokdah、Theodore Sulkowski、David Cochran、Mar-Lee McKean、Elaine Quinet

  DOI：10.1016/s0960-894x(00)00338-3

  日期：2000.8

  A series of 2-substituted sulfanyl-3,5-dihydro-imidazole-4-one and 2-substituted sulfanyl-1H-imidazole-4,5-diones was prepared and shown to increase high density lipoprotein cholesterol over other lipid fractions. Compound If showed efficacy in additional animal models. The major metabolite of If was isolated and its synthesis is reported. The effects of the metabolite on the lipid profile in rats were investigated. (C) 2000 Elsevier Science Ltd. All rights reserved.