Boc-Tic-Ser(Ac)-Bid | 1184170-67-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Tic-Ser(Ac)-Bid
• CAS: 1184170-67-9
• 化学式: C₂₆H₃₀N₄O₅
• 分子量: 478.548
• InChiKey: SRUVCWXSLZXGMY-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.65
• 重原子数：
  35.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  113.62
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  Boc-Tic-Ser(Ac)-Bid 在 三氟乙酸 作用下， 反应 0.5h， 以93%的产率得到
  参考文献：
  名称：

  Influence of the Side Chain Next to C-Terminal Benzimidazole in Opioid Pseudopeptides Containing the Dmt-Tic Pharmacophore

  摘要：

  To improve the structure-activity studies of the lead 6 opioid agonist H-Dmt-Tic-Asp*-Bid, we synthesized and pharmacologically characterized a series of analogues in which the side chain next to 1H-benzimidazole-2-yl (Bid) was substituted by those endowed with different chemical properties. Interesting results were obtained: (1) only Gly, Ala, and Asp resulted in delta agonism, (2) Phe yielded delta antagonism, (3) and all other residues except Glu (devoid of any activity) gave mu agonism.

  DOI：

  10.1021/jm900686q
• 作为产物：
  描述：

  、 N-叔丁氧羰基-(S)-1,2,3,4-四氢异喹啉-3-羧酸 在 N-甲基吗啉 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以85%的产率得到Boc-Tic-Ser(Ac)-Bid
  参考文献：
  名称：

  Influence of the Side Chain Next to C-Terminal Benzimidazole in Opioid Pseudopeptides Containing the Dmt-Tic Pharmacophore

  摘要：

  To improve the structure-activity studies of the lead 6 opioid agonist H-Dmt-Tic-Asp*-Bid, we synthesized and pharmacologically characterized a series of analogues in which the side chain next to 1H-benzimidazole-2-yl (Bid) was substituted by those endowed with different chemical properties. Interesting results were obtained: (1) only Gly, Ala, and Asp resulted in delta agonism, (2) Phe yielded delta antagonism, (3) and all other residues except Glu (devoid of any activity) gave mu agonism.

  DOI：

  10.1021/jm900686q