5-AMINO-N-[(1-BUTYL-4-PIPERIDINYL)METHYL]-6-CHLORO-2-PHENYLIMIDAZO[1,2-A]PYRIDINE-8-CARBOXAMIDE HYDROCHLORIDE SALT | 519148-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-AMINO-N-[(1-BUTYL-4-PIPERIDINYL)METHYL]-6-CHLORO-2-PHENYLIMIDAZO[1,2-A]PYRIDINE-8-CARBOXAMIDE HYDROCHLORIDE SALT
• 英文别名: 5-amino-N-[(1-butylpiperidin-4-yl)methyl]-6-chloro-2-phenylimidazo[1,2-a]pyridine-8-carboxamide;hydrochloride
• CAS: 519148-42-6
• 化学式: C₂₄H₃₀ClN₅O*ClH
• 分子量: 476.449
• InChiKey: HEIICJXWXZHLTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  75.7
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Imidazopyridine compounds as 5-HT4 receptor modulators
  申请人：——

  公开号：US20040034226A1

  公开（公告）日：2004-02-19

  This invention provides a compound of the formula (I): 1 or the pharmaceutically acceptable salts thereof wherein R 1 is hydrogen, halo or alkyl; R 2 and R 3 are independently hydrogen, alkyl, alkenyl, alkynyl, aminoalkyl or hydroxyalkyl; or R 2 and R 3 taken together with the nitrogen atom to which they are E attached may form hetrocyclic; R 4 is hydrogen, halo, acyl, amino, amido, aryl, arylalkyl, or heteroaryl; R 5 is hydrogen, halo, alkyl, alkenyl, alkynyl, acyl, amino, amido, aryl, arylalkyl, or heteroaryl; R 6 is hydrogen, alkyl or alkoxyalkyl; X is NR 9 wherein R 9 is hydrogen or alkyl; and Y is (CR 7 R 8 ) n wherein n is an integer from 0 to 5. These compounds have 5-HT 4 receptor binding activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, Functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans. This invention also provides a pharmaceutical composition comprising the above compound.

  本发明提供了式(I)的化合物或其药学上可接受的盐，其中R1是氢、卤素或烷基；R2和R3分别是氢、烷基、烯基、炔基、氨基烷基或羟基烷基；或者R2和R3与它们连接的氮原子一起可以形成杂环；R4是氢、卤素、酰基、氨基、酰胺、芳基、芳基烷基或杂芳基；R5是氢、卤素、烷基、烯基、炔基、酰基、氨基、酰胺、芳基、芳基烷基或杂芳基；R6是氢、烷基或烷氧基烷基；X是NR9，其中R9是氢或烷基；Y是(CR7R8)n，其中n是0到5的整数。这些化合物具有5-HT4受体结合活性，因此可用于哺乳动物，特别是人类的胃食管反流病、非溃疡性消化不良、功能性消化不良、肠易激综合征或类似疾病的治疗。本发明还提供了包含上述化合物的制药组合物。
• US6624162B2
  申请人：——

  公开号：US6624162B2

  公开（公告）日：2003-09-23