5-(4-carbamoyl-3-{4-[(15-{4-[4-carbamoyl-6-(3-carboxy-4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]phenyl}-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl)carbamoyl]phenyl}-1H-pyrazolo[3,4-b]pyridin-6-yl)-2-fluorobenzoic acid | 1446176-49-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(4-carbamoyl-3-{4-[(15-{4-[4-carbamoyl-6-(3-carboxy-4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]phenyl}-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl)carbamoyl]phenyl}-1H-pyrazolo[3,4-b]pyridin-6-yl)-2-fluorobenzoic acid
• 英文别名: 5-[4-carbamoyl-3-[4-[3-[2-[2-[3-[[4-[4-carbamoyl-6-(3-carboxy-4-fluorophenyl)-2H-pyrazolo[3,4-b]pyridin-3-yl]benzoyl]amino]propoxy]ethoxy]ethoxy]propylcarbamoyl]phenyl]-2H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid
• CAS: 1446176-49-3
• 化学式: C₅₂H₄₆F₂N₁₀O₁₁
• 分子量: 1024.99
• InChiKey: FQLSXRGLADLKGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  75
• 可旋转键数：
  24
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  330
• 氢给体数：
  8
• 氢受体数：
  17

文献信息

• FGF Receptor (FGFR) Agonist Dimeric Compounds, Process for the Preparation Thereof and Therapeutic Use Thereof
  申请人：Sanofi

  公开号：US20150011579A1

  公开（公告）日：2015-01-08

  The invention relates to novel heterocyclic compounds which are pyrazolopyridine derivatives that induce fibroblast growth factor receptor (FGFR) dimerization, having the general formula: M 1 -L-M 2 in which M 1 or M 2 , which may be identical or different, each represent, independently of one another, a monomer unit M and L represents a linker group which links M 1 and M 2 covalently with the monomer unit which follows: Process for the preparation thereof and therapeutic use thereof.

  本发明涉及一种新型杂环化合物，它是吡唑吡啶衍生物，能引起成纤维细胞生长因子受体（FGFR）二聚化，其一般式为：M1-L-M2，其中M1或M2，可以相同也可以不同，分别独立地表示单体单位M，L表示连接M1和M2与其后面的单体单位的连接基：其制备方法和治疗用途。
• FGF RECEPTOR (FGFR) AGONIST DIMERIC COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
  申请人：SANOFI

  公开号：EP2797917B1

  公开（公告）日：2016-08-10
• US9034898B2
  申请人：——

  公开号：US9034898B2

  公开（公告）日：2015-05-19