(E)-3-cyano-N-methylmethacrylamide | 91305-88-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-3-cyano-N-methylmethacrylamide
• 英文别名: (E)-3-cyano-N,2-dimethylprop-2-enamide
• CAS: 91305-88-3
• 化学式: C₆H₈N₂O
• 分子量: 124.142
• InChiKey: GFJFLSTVMWELSI-HWKANZROSA-N

物化性质

• 沸点：
  309.8±34.0 °C(Predicted)
• 密度：
  1.031±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-3-cyano-N-methylmethacrylamide 以47%的产率得到(Z)-3-cyano-N-methylmethacrylamide
  参考文献：
  名称：

  与软氰化物阴离子反应将新的1,3-恶嗪环转化为吡咯

  摘要：

  用氰化钾处理2 H -1,3-恶嗪-2,4（3 H）-二酮（1）引起环转化，得到5-亚氨基-1,5-二氢-2 H-吡咯-2-酮（2）。

  DOI：

  10.1039/c39840000332
• 作为产物：
  描述：

  3,5-Dimethyl-1,3-oxazine-2,4-dione 、 氰化钾 以73%的产率得到
  参考文献：
  名称：

  YOGO, MOTOI;HIROTA, KOSAKU;MAKI, YOSHIFUMI, J. CHEM. SOC. CHEM. COMMUN., 1984, N 6, 332-333

  摘要：

  DOI：

文献信息

• Novel ring tansformation of 1,3-oxazines into pyrroles by the reaction with soft cyanide anion
  作者：Motoi Yogo、Kosaku Hirota、Yoshifumi Maki

  DOI：10.1039/c39840000332

  日期：——

  Treatment of 2H-1,3-oxazine-2,4(3H)-diones (1) with potassium cyanide caused a ring transformation to afford 5-imino-1,5-dihydro-2H-pyrrol-2-ones (2).

  用氰化钾处理2 H -1,3-恶嗪-2,4（3 H）-二酮（1）引起环转化，得到5-亚氨基-1,5-二氢-2 H-吡咯-2-酮（2）。
• YOGO, MOTOI;HIROTA, KOSAKU;MAKI, YOSHIFUMI, J. CHEM. SOC. PERKIN TRANS., 1984, N 9, 2097-2102
  作者：YOGO, MOTOI、HIROTA, KOSAKU、MAKI, YOSHIFUMI

  DOI：——

  日期：——
• NUCLEIC ACID PROBE AND NUCLEIC ACID SEQUENCING METHOD
  申请人：MGI TECH CO., LTD.

  公开号：US20200277673A1

  公开（公告）日：2020-09-03

  A nucleic acid probe and a nucleic acid sequencing method for performing sequencing while ligating nucleic acids. The nucleic acid probe is a DNA sequencing probe, comprising a first moiety, a second moiety, a linker, and a detectable label. A base of the first moiety is A, T, U, C, or G, a base of the second moiety is a random base and/or a universal base, and 3 bases or more are present in the second moiety. The first moiety and the second moiety are ligated via the linker, the connection between the first moiety and the ligation can be cleaved, and the detectable label is ligated to the second moiety or the linker. The above probe, a combination formed therewith, or a sequencing method using the same can reduce the number or types of probes in nucleic acid sequencing, thereby reducing cost.
• NUCLEIC ACID SEQUENCING METHOD AND NUCLEIC ACID SEQUENCING KIT
  申请人：BGI SHENZHEN

  公开号：US20210363576A1

  公开（公告）日：2021-11-25

  Provided are a nucleic acid sequencing method and a nucleic acid sequencing kit. The kit comprises a nucleic acid probe, a ligase, dNTP having a blocking group attached to a 3′ end, a polymerase, a reagent 1 for excising the blocking group attached to the 3′ end of the dNTP, and a reagent 2 for excising the remaining nucleotides on the nucleic acid probe that are not bound to a to-be-tested base group.
• Yogo, Motoi; Hirota, Kosaku; Maki, Yoshifumi, Journal of the Chemical Society. Perkin transactions I, 1984, p. 2097 - 2102
  作者：Yogo, Motoi、Hirota, Kosaku、Maki, Yoshifumi

  DOI：——

  日期：——