5-(2-{[(Tert-butoxy)carbonyl]amino}ethyl)-1,2-oxazole-3-carboxylicacid | 2287289-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(2-{[(Tert-butoxy)carbonyl]amino}ethyl)-1,2-oxazole-3-carboxylicacid
• 英文别名: 5-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]-1,2-oxazole-3-carboxylic acid
• CAS: 2287289-97-6
• 化学式: C₁₁H₁₆N₂O₅
• 分子量: 256.25
• InChiKey: JENSYBUZSUONAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROARYLES UTILES EN TANT QU'INHIBITEURS DE KINASE RAF
  申请人：BIOGEN IDEC INC

  公开号：WO2010078408A1

  公开（公告）日：2010-07-08

  The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.

  本发明提供了一种化合物，其化学式为（I），可用作Raf蛋白激酶的抑制剂。本发明还提供了这些化合物的组合物，以及治疗Raf介导疾病的方法。
• PYRIMIDINE DERIVATIVES USEFUL AS RAF KINASE INHIBITORS
  申请人：Sunesis Pharmaceuticals, Inc.

  公开号：EP2167489A2

  公开（公告）日：2010-03-31
• HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
  申请人：Sunesis Pharmaceuticals, Inc.

  公开号：EP2167497A2

  公开（公告）日：2010-03-31
• HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
  申请人：MILLENNIUM PHARMACEUTICALS, INC.

  公开号：EP2379513A1

  公开（公告）日：2011-10-26
• [EN] HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES UTILES EN TANT QU'INHIBITEURS DE LA KINASE RAF
  申请人：SUNESIS PHARMACEUTICALS INC

  公开号：WO2009006404A2

  公开（公告）日：2009-01-08

  The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently selected from nitrogen, oxygen, or sulfur; L1 is a direct bond of an optionally substituted, straight or branched C1-6 alkylene chain; L2 is a direct bond, or is an optionally substituted, straight or branched C1-6 alkylene chain wherein 1 or 2 methylene units of L2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO2-, -SO2N(R)-, -N(R)SO2-, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydrogen or an optionally substituted C1-6 aliphatic group;