4-(Diethylamino)-2-propoxybenzaldehyde | 916166-34-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(Diethylamino)-2-propoxybenzaldehyde
• 英文别名: 4-(diethylamino)-2-propoxybenzaldehyde
• CAS: 916166-34-2
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.326
• InChiKey: WLJAYXYHHSMLJP-UHFFFAOYSA-N

物化性质

• 沸点：
  363.6±27.0 °C(Predicted)
• 密度：
  1.027±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(Diethylamino)-2-propoxybenzaldehyde 、 2,3-diaminomaleonitrile 在 哌啶 作用下， 以 苯 为溶剂， 反应 8.0h， 以71.8%的产率得到2,3-bis((4-(diethylamino)-2-propoxybenzylidene)amino)but-2-enedinitrile
  参考文献：
  名称：

  Effect of phenyl ring substitution on J-aggregate formation ability of novel bisazomethine dyes in vapour-deposited films

  摘要：

  Bisazomethine dyes, which are synthesized using diaminomaleonitrile and aminobenzaldehydes, exhibit red fluorescence in solution and in the solid state. Several bisazomethine dyes are known to form J-aggregates in vapour-deposited films. In this work, novel bisazomethine dyes were synthesized and the effect of phenyl ring substitution on the J-aggregate formation in vapour-deposited films was examined. The optical properties of the dyes were examined in solution and in the solid state through molecular orbital calculations. Four derivatives were found to form J-aggregates in vapour-deposited films as determined from the shape of the spectrum and the absorption edge. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2010.11.009
• 作为产物：
  描述：

  4-(二乙氨基)水杨醛 、 溴丙烷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以77.3%的产率得到4-(Diethylamino)-2-propoxybenzaldehyde
  参考文献：
  名称：

  Effect of phenyl ring substitution on J-aggregate formation ability of novel bisazomethine dyes in vapour-deposited films

  摘要：

  Bisazomethine dyes, which are synthesized using diaminomaleonitrile and aminobenzaldehydes, exhibit red fluorescence in solution and in the solid state. Several bisazomethine dyes are known to form J-aggregates in vapour-deposited films. In this work, novel bisazomethine dyes were synthesized and the effect of phenyl ring substitution on the J-aggregate formation in vapour-deposited films was examined. The optical properties of the dyes were examined in solution and in the solid state through molecular orbital calculations. Four derivatives were found to form J-aggregates in vapour-deposited films as determined from the shape of the spectrum and the absorption edge. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2010.11.009

文献信息

• [EN] COMPOUNDS FOR USE IN CANCER THERAPY<br/>[FR] COMPOSÉS POUR UTILISATION DANS LA THÉRAPIE DU CANCER
  申请人：NUHOPE LLC

  公开号：WO2013024447A1

  公开（公告）日：2013-02-21

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  申请人：Connor James R.

  公开号：US20150065531A1

  公开（公告）日：2015-03-05

  Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may be used for reducing tumor size in a mammalian subject and for inducing apoptosis in a tumor cell. The methods are effective on tumor cells that are resistant to drugs such as temozolomide, doxorubicin, and geldanamycin, as well as non-resistant tumor cells. Further provided are barbiturate and thiobarbiturates diene compounds for use in treating cancer, and uses, methods and compositions relating to these compounds.

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