N-(2-(N-alanyl)-1,2,3,4-tetrahydrocarboline-3-carbonyl)-2-amino-2-deoxy-D-glucosamine | 1370030-98-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(2-(N-alanyl)-1,2,3,4-tetrahydrocarboline-3-carbonyl)-2-amino-2-deoxy-D-glucosamine
• CAS: 1370030-98-0
• 化学式: C₂₁H₂₈N₄O₇
• 分子量: 448.476
• InChiKey: VGYQUVBHAPWBTF-OGVWHCEKSA-N

反应信息

• 作为产物：
  描述：

  N-(2-(N-Boc-alanyl)-1,2,3,4-tetrahydrocarboline-3-carbonyl)-2-amino-2-deoxy-D-glucosamine 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 反应 0.5h， 生成 N-(2-(N-alanyl)-1,2,3,4-tetrahydrocarboline-3-carbonyl)-2-amino-2-deoxy-D-glucosamine 、 N-(2-(N-alanyl)-1,2,3,4-tetrahydrocarboline-3-carbonyl)-2-amino-2-deoxy-D-glucosamine
  参考文献：
  名称：

  Design, synthesis, and evaluation of a novel class of 2,3-disubstituted-tetrahydro-β-carboline derivatives

  摘要：

  Several novel tetrahydro-beta-carboline derivatives with amino acid residues at the 2-position and a glucosamine group at the 3-position of the tetrahydro-beta-carboline nucleus were synthesized from a readily available starting material, tryptophane, and were evaluated for their anti-inflammatory activity in the present study. Our results showed that all of the derivatives tested exhibited a significant inhibition of xylene-induced inflammation in mice. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.020