N-Benzyl-3-(6-fluoro-3-oxo-3,5-dihydro-pyrazolo[4,3-c]-quinolin-2-yl)-benzamide | 702704-80-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-Benzyl-3-(6-fluoro-3-oxo-3,5-dihydro-pyrazolo[4,3-c]-quinolin-2-yl)-benzamide
• CAS: 702704-80-1
• 化学式: C₂₄H₁₇FN₄O₂
• 分子量: 412.423
• InChiKey: DHNUGWAQKUGFAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.89
• 重原子数：
  31.0
• 可旋转键数：
  4.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  79.78
• 氢给体数：
  2.0
• 氢受体数：
  4.0

文献信息

• Immunomodulatory compounds
  申请人：ACTIVE BIOTECH AB

  公开号：US20040116461A1

  公开（公告）日：2004-06-17

  The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.

  本发明涉及新颖的杂环化合物，其制备方法，含有它们的组合物，以及用于临床治疗可能受益于免疫调节的医疗状况的方法和用途，包括类风湿关节炎、多发性硬化症、糖尿病、哮喘、移植、系统性红斑狼疮和牛皮癣。更具体地，本发明涉及新颖的杂环化合物，它们是CD80拮抗剂，能够抑制CD80和CD28之间的相互作用。
• Pyrazoloquinolines with immunomodulating activity
  申请人：Active Biotech AB

  公开号：EP1813616A2

  公开（公告）日：2007-08-01

  The present invention relates to novel heterocyclic compounds of the formula (I), to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.

  本发明涉及式(I)的新型杂环化合物、其制备方法、含有它们的组合物，以及用于临床治疗可能受益于免疫调节的病症的方法和用途，这些病症包括类风湿性关节炎、多发性硬化症、糖尿病、哮喘、移植、系统性红斑狼疮和银屑病。更具体地说，本发明涉及新型杂环化合物，它们是 CD80 拮抗剂，能够抑制 CD80 和 CD28 之间的相互作用。
• PYRAZOLOQUINOLINES WITH IMMUNOMODULATING ACTIVITY
  申请人：Active Biotech AB

  公开号：EP1562944B1

  公开（公告）日：2007-02-14
• US7081456B2
  申请人：——

  公开号：US7081456B2

  公开（公告）日：2006-07-25
• US7291612B2
  申请人：——

  公开号：US7291612B2

  公开（公告）日：2007-11-06