ethyl 2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexyl]amino]acetate | 935861-67-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexyl]amino]acetate
• CAS: 935861-67-9
• 化学式: C₂₃H₃₇N₃O₆
• 分子量: 451.563
• InChiKey: KOYNXXJUIAOQCC-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  32
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  ethyl 2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexyl]amino]acetate 、 胸腺嘧啶-1-乙酸 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 36.0h， 以79%的产率得到
  参考文献：
  名称：

  由L-赖氨酸构建的γ-取代的肽核酸是用于多功能展示的通用支架。

  摘要：

  DOI：

  10.1002/anie.200603483
• 作为产物：
  描述：

  甘氨酸乙酯盐酸盐 、 benzyl {(5S)-5-[(tert-butoxycarbonyl)amino]-6-oxohexyl}carbamate 在 三乙胺 、 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 为溶剂， 反应 1.92h， 以310 mg的产率得到ethyl 2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexyl]amino]acetate
  参考文献：
  名称：

  由L-赖氨酸构建的γ-取代的肽核酸是用于多功能展示的通用支架。

  摘要：

  DOI：

  10.1002/anie.200603483

文献信息

• PROGRAMMABLE SELF-ASSEMBLED NANOSTRUCTURES BASED ON SIDECHAIN-MODIFIED PNA FOR THE MULTIVALENT DISPLAY OF LIGANDS
  申请人：The U.S.A. as represented by the Secretary, Department of Health and Human Services

  公开号：EP2569328B1

  公开（公告）日：2016-12-14
• cGAP-PNA MULTIVALENT PEPTIDE NUCLEIC ACID LIGAND DISPLAY
  申请人：THE USA, AS REPRESENTED BY THE SECRETARY, DEPART- MENT OF HEALTH AND HUMAN SERVICES

  公开号：US20170002355A1

  公开（公告）日：2017-01-05

  Described herein are compositions composed of peptide nucleic acid strands. In some aspects the peptide nucleic acid strands are complementary to at least a portion of another peptide nucleic acid strand that may have one or more gamma substituents, where the ratio of PNA strands is least 1:1. Certain gamma substituents are capable of effecting attachment of a PNA strand to a cell. The disclosure also concerns construction of nanostructure platforms and vaccines and use of the inventive compositions in inhibiting disease states in mammals.
• [EN] PROGRAMMABLE SELF-ASSEMBLED NANOSTRUCTURES BASED ON SIDECHAIN-MODIFIED PNA FOR THE MULTIVALENT DISPLAY OF LIGANDS<br/>[FR] NANOSTRUCTURES AUTO-ASSEMBLÉES PROGRAMMABLES BASÉES SUR UN APN À CHAÎNES LATÉRALES MODIFIÉES POUR LA PRÉSENTATION MULTIVALENTE DE LIGANDS
  申请人：USA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH & HUMAN SERVICES

  公开号：WO2011143323A2

  公开（公告）日：2011-11-17

  The invention concerns compositions comprising strands of polynucleotide and strands of PNA, each PNA strand comprising: (i) from 2 to 50 nucleobase subunits and (ii) one or more gamma substituents. The PNA strands are complementary to at least a portion of at least some of the polynucleotide strands, and the molar ratio of PNA strands to polynucleotide strands being at least 1:1. Certain gamma substituents are capable of effecting attachment of a PNA strand to a cell. The invention also concerns construction of nanostructure platforms and vaccines and use of the inventive compositions in inhibiting disease states in mammals.
• [EN] cGAP-PNA MULTIVALENT PEPTIDE NUCLEIC ACID LIGAND DISPLAY<br/>[FR] AFFICHAGE DE LIGAND ACIDE NUCLÉIQUE PEPTIDIQUE POLYVALENT CGAP-PNA
  申请人：US HEALTH

  公开号：WO2015112438A1

  公开（公告）日：2015-07-30

  Described herein are compositions composed of peptide nucleic acid strands. In some aspects the peptide nucleic acid strands are complementary to at least a portion of another peptide nucleic acid strand that may have one or more gamma substituents, where the ratio of PNA strands is least 1:1. Certain gamma substituents are capable of effecting attachment of a PNA strand to a cell. The disclosure also concerns construction of nanostructure platforms and vaccines and use of the inventive compositions in inhibiting disease states in mammals.