{2-[(2S)-2-pyrrolidinyl]ethyl}amine | 1309562-00-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: {2-[(2S)-2-pyrrolidinyl]ethyl}amine
• 英文别名: 2-[(2S)-pyrrolidin-2-yl]ethanamine
• CAS: 1309562-00-2
• 化学式: C₆H₁₄N₂
• 分子量: 114.191
• InChiKey: MCULVESJRLLZOP-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  {2-[(2S)-2-pyrrolidinyl]ethyl}amine 在 palladium 10% on activated carbon 氢气 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 18.17h， 生成 (3aS,13aS)-N-[(2,4-difluorophenyl)methyl]-8-hydroxy-7,9-dioxo-1,2,3,3a,4,5,7,9,13,13a-decahydropyrido[1',2':4,5]pyrazino[1,2-a]pyrrolo[1,2-c]pyrimidine-10-carboxamide
  参考文献：
  名称：

  WO2006/116764

  摘要：

  公开号：
• 作为产物：
  描述：

  (S)-2-(甲苯磺酰氧基甲基)吡咯烷-1-甲酸叔丁酯 在 Raney-Ni 盐酸 、 氨 、 水 、 氢气 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 水 、 二甲基亚砜 为溶剂， 20.0~90.0 ℃ 、344.75 kPa 条件下， 反应 10.0h， 生成 {2-[(2S)-2-pyrrolidinyl]ethyl}amine
  参考文献：
  名称：

  WO2006/116764

  摘要：

  公开号：

文献信息

• [EN] BICYCLIC COMPOUNDS HAVING ACTIVITY AT THE CXCR4 RECEPTOR<br/>[FR] COMPOSÉS BICYCLIQUES AYANT UNE ACTIVITÉ SUR LE RÉCEPTEUR CXCR4
  申请人：ALLERGAN INC

  公开号：WO2009143058A1

  公开（公告）日：2009-11-26

  A compound represented by the structural formula (I): Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

  由结构式(I)表示的化合物：还公开了相关的治疗方法、组合物和药物。
• <scp>d</scp>-Prolyl-2-(trifluoromethylsulfonamidopropyl)pyrrolidine: An Organocatalyst for Asymmetric Michael Addition of Aldehydes to β-Nitroalkenes at Ambient Conditions
  作者：Amol B. Gorde、Ramesh Ramapanicker

  DOI：10.1021/acs.joc.8b02945

  日期：2019.2.1

  yrrolidines and their d-prolinamides were prepared and screened as organocatalysts for the Michael addition reaction of aldehydes with β-nitroalkenes at rt and without the use of additives. d-Prolyl-2-(trifluoromethylsulfonamidopropyl)pyrrolidine was found to be the best among the molecules studied, which yielded γ-nitro aldehydes in very high yields (up to 95%), with high diastereoselectivity (up

  制备了四个2-（三氟甲基磺酰胺基烷基）吡咯烷及其d-脯氨酰胺，并筛选出在室温下且不使用添加剂的情况下，醛与β-硝基烯烃的迈克尔加成反应的有机催化剂。发现d -Prolyl-2-（三氟甲基磺酰胺基丙基）吡咯烷是所研究分子中最好的，它以非常高的产率（高达95％），高的非对映选择性（高达> 99：1）和高的非对映选择性产生γ-硝基醛。具有高达97％的ee。
• Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity
  申请人：Johns Brian Alvin

  公开号：US20090318421A1

  公开（公告）日：2009-12-24

  The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. (wherein Z 1 is NR 4 ; R 1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO 2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R 2 is optionally substituted aryl; R 3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R 4 and Z 2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.

  本发明提供了一种新型化合物(I)，如下所示，具有抗病毒活性，特别是HIV整合酶抑制活性，以及含有该化合物的药物，特别是抗HIV药物，以及其制备方法和中间体。(其中Z1为NR4;R1为氢或低碳基;X为单键，从O、S、SO、SO2和NH中选择的杂原子基团，或低碳基或低碳烯基，在其中杂原子基团可以介入;R2为可选取代芳基;R3为氢、卤素、羟基、可选取代的低碳基等;R4和Z2共同形成环，形成多环化合物，包括例如三环或四环化合物。
• Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness
  申请人：Shionogi & Co., Ltd.

  公开号：US08129385B2

  公开（公告）日：2012-03-06

  The present invention is directed to a class of substituted 5-hydroxy-3,4,6,9,9a,10-hexahydro-2H-1-oxa-4a,8a-diaza-anthracene-6,10-diones useful as anti-HIV agents. The compounds have the formula: Z═O; R20, R21, R22, R23, R24 and R25 independently are hydrogen, C1-C8 alkyl, (C6-C14)aryl-(C1-C8)alkyl, C6-C14 aryl, or alkoxy; the stereochemistry of an asymmetric carbon represented by * shows R- or S-configuration, or a mixture thereof; RX is hydrogen; R14 is hydrogen or optionally substituted lower alkyl; R3 is hydrogen; R1 is hydrogen or lower alkyl; R is halogen; and m is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.

  本发明涉及一类取代的5-羟基-3,4,6,9,9a,10-六氢-2H-1-氧杂-4a,8a-二氮蒽-6,10-二酮，可用作抗HIV剂。化合物的式子为：Z = O；R20，R21，R22，R23，R24和R25分别是氢，C1-C8烷基，(C6-C14)芳基-(C1-C8)烷基，C6-C14芳基或烷氧基；由*表示的不对称碳的立体化学构型显示为R-或S-构型，或其混合物；RX为氢；R14为氢或可选取代的低烷基；R3为氢；R1为氢或低烷基；R为卤素；m为1、2或3；或其药学上可接受的盐。
• POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
  申请人：Johns Brian Alvin

  公开号：US20120115875A1

  公开（公告）日：2012-05-10

  The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. (wherein Z 1 is NR 4 ; R 1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO 2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R 2 is optionally substituted aryl; R 3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R 4 and Z 2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.

  本发明提供了一种新型化合物（I），其具有抗病毒活性，特别是HIV整合酶抑制活性，以及含有该化合物的药物，特别是抗HIV药物，以及其制备方法和中间体。（其中Z1为NR4；R1为氢或低碳基；X为单键，从O、S、SO、SO2和NH中选择的杂原子基团，或低碳基或低碳烯基，其中杂原子基团可以介入；R2为可选取代芳基；R3为氢、卤素、羟基、可选取代的低碳基等；R4和Z2共同形成环，形成多环化合物，包括三环或四环化合物等。）