(2S,10R,10aS)-9-allyloxy-10-hydroxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-triisopropylsilyloxy-3'-(2-allylphenyl)-propanoate | 1352212-99-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: (2S,10R,10aS)-9-allyloxy-10-hydroxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-triisopropylsilyloxy-3'-(2-allylphenyl)-propanoate
• CAS: 1352212-99-7
• 化学式: C₄₃H₅₆N₂O₆Si
• 分子量: 725.013
• InChiKey: PTYFQAFLHBMALG-SXFUFCAFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.25
• 重原子数：
  52.0
• 可旋转键数：
  16.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  97.33
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  (2S,10R,10aS)-9-allyloxy-10-hydroxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-triisopropylsilyloxy-3'-(2-allylphenyl)-propanoate 在 左旋樟脑磺酸 、 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以16 mg的产率得到
  参考文献：
  名称：

  Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation

  摘要：

  A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been synthesized. Both the internally bridged analogs 37-39, 41 and the open- chain analogs 27-29 and 43 were prepared. The bridged analogs 37-39 and 41 were synthesized by Grubbs' metatheses of compounds 30-32 and 33, which, in turn, were prepared by coupling beta-lactams 24-26 with alcohols 22 and 23. Both the bridged and the open- chain analogs showed moderate to good cytotoxicity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.010
• 作为产物：
  描述：

  2-iodo-3-methoxybenzaldehyde 在 吡啶 、 sodium tetrahydroborate 、 正丁基锂 、 氢氟酸 、 三溴化硼 、 三乙酰氧基硼氢化钠 、 sodium hydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 10.67h， 生成 (2S,10R,10aS)-9-allyloxy-10-hydroxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-triisopropylsilyloxy-3'-(2-allylphenyl)-propanoate
  参考文献：
  名称：

  Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation

  摘要：

  A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been synthesized. Both the internally bridged analogs 37-39, 41 and the open- chain analogs 27-29 and 43 were prepared. The bridged analogs 37-39 and 41 were synthesized by Grubbs' metatheses of compounds 30-32 and 33, which, in turn, were prepared by coupling beta-lactams 24-26 with alcohols 22 and 23. Both the bridged and the open- chain analogs showed moderate to good cytotoxicity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.010