threo-3-Hydroxy-2-methyl-leucin

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: threo-3-Hydroxy-2-methyl-leucin
• 英文别名: (2S,3R)-2-amino-3-hydroxy-2,4-dimethylpentanoic acid
• 化学式: C₇H₁₅NO₃
• 分子量: 161.201
• InChiKey: TZVNDZVJZXCGMU-VDTYLAMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  copper(II) alaninate 、 异丁醛 生成 threo-3-Hydroxy-2-methyl-leucin 、 (+/-)-anti-2-Amino-3-hydroxy-2,4-dimethylpentanoic acid
  参考文献：
  名称：

  Neue aliphatische 2-Amino-3-hydroxysäuren, II

  摘要：

  DOI：

  10.1515/bchm2.1964.337.1.40

文献信息

• ENGINEERED ALDOLASE POLYPEPTIDES AND USES THEREOF
  申请人：Enzymaster (Ningbo) Bio-Engineering Co., Ltd

  公开号：US20200123525A1

  公开（公告）日：2020-04-23

  The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.
• ENGINEERED POLYPEPTIDES AND THEIR APPLICATIONS IN THE SYNTHESIS OF BETA-HYDROXY-ALPHA-AMINO ACIDS
  申请人：Enzymaster (Ningbo) Bio-Engineering Co., Ltd.

  公开号：US20210284987A1

  公开（公告）日：2021-09-16

  The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.