4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-3-(1-pyrrolyl)aniline | 439683-53-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-3-(1-pyrrolyl)aniline
• 英文别名: 4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy-3-pyrrol-1-ylaniline
• CAS: 439683-53-1
• 化学式: C₁₆H₁₁ClF₃N₃O
• 分子量: 353.731
• InChiKey: RULOLCLUPIEUPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  53.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-3-(1-pyrrolyl)aniline 、 2-氯-5-硝基苯甲酰氯 在 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 N-(4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-3-(1-pyrrolyl)phenyl)-2-chloro-5-nitrobenzamide
  参考文献：
  名称：

  EP1344525

  摘要：

  公开号：

文献信息

• Aniline derivatives or salts thereof and cytokine production inhibitors containing the same
  申请人：——

  公开号：US20040048891A1

  公开（公告）日：2004-03-11

  The present invention provides a cytokine production inhibitor containing as an active ingredient an aniline derivative of the formula (I) or a salt thereof: 1 [wherein A is CO or SO 2 ; Cy is an aryl group or a heterocyclic group; each of R 1 and R 2 which are independent of each other, is a halogen atom, a cyano group, a nitro group, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, a cycloalkyl group which may be substituted, a cycloalkenyl group which may be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an amino group which may be substituted or a —B-Q group; R 3 is a -M 1 -M 2 -R 5 group; R 4 is a hydrogen atom or an alkyl group which may be substituted; x is an integer of from 0 to 5; y is an integer of from 0 to 4; and z is an integer of from 0 to 1].

  本发明提供一种细胞因子生成抑制剂，其作为活性成分包含式（I）的苯胺衍生物或其盐：1＆lsqb;其中A是CO或SO2；Cy是芳基或杂环基；R1和R2各自独立地是卤素原子，氰基，硝基，可被取代的烷基，可被取代的烯基，可被取代的炔基，可被取代的环烷基，可被取代的环烯基，可被取代的芳基，可被取代的杂环基，可被取代的氨基或—B-Q基；R3是-M1-M2-R5基团；R4是氢原子或可被取代的烷基；x是0到5的整数；y是0到4的整数；z是0到1的整数＆rsqb;。
• ANILINE DERIVATIVES OR SALTS THEREOF AND CYTOKINE PRODUCTION INHIBITORS CONTAINING THE SAME
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP1344525A1

  公开（公告）日：2003-09-17

  The present invention provides a cytokine production inhibitor containing as an active ingredient an aniline derivative of the formula (I) or a salt thereof: [wherein A is CO or SO2; Cy is an aryl group or a heterocyclic group; each of R1 and R2 which are independent of each other, is a halogen atom, a cyano group, a nitro group, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, a cycloalkyl group which may be substituted, a cycloalkenyl group which may be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an amino group which may be substituted or a - B-Q group; R3 is a -M1-M2-R5 group; R4 is a hydrogen atom or an alkyl group which may be substituted; x is an integer of from 0 to 5; y is an integer of from 0 to 4; and z is an integer of from 0 to 1].

  本发明提供了一种细胞因子产生抑制剂，其活性成分含有式(I)的苯胺衍生物或其盐： [其中 A 是 CO 或 SO2；Cy 是芳基或杂环基；相互独立的 R1 和 R2 分别是卤素原子、氰基、硝基、可被取代的烷基、可被取代的烯基、可被取代的炔基、可被取代的环烷基、可被取代的环烯基、可被取代的芳基、可被取代的杂环基、可被取代的氨基或 -B-Q 基团；R3 是-M1-M2-R5 基团；R4 是氢原子或可被取代的烷基；x 是 0 至 5 的整数；y 是 0 至 4 的整数；z 是 0 至 1 的整数]。
• US7132546B2
  申请人：——

  公开号：US7132546B2

  公开（公告）日：2006-11-07
• EP1344525
  申请人：——

  公开号：——

  公开（公告）日：——