1-苯基-1H-四唑-5-硫醇 钠盐 | 15052-19-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1-苯基-1H-四唑-5-硫醇 钠盐
• 中文别名: 1-甲基-5-巯基四氮唑钠盐；1-苯基-1H-四唑-5-硫醇钠盐
• 英文名称: 1-Phenyltetrazol-5-thiol sodium salt
• CAS: 15052-19-4
• 化学式: C7H6N4NaS
• 分子量: 201.21
• InChiKey: IRSCLWYPLNPCQX-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C(lit.)
• 溶解度：
  水: 可溶1g/15ml, 透明

计算性质

• 辛醇/水分配系数(LogP)：
  0.94
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2933990090
• WGK Germany：
  3
• 危险标志：
  GHS07
• 危险性描述：
  H315,H319,H335
• 危险性防范说明：
  P261,P305 + P351 + P338

反应信息

• 作为反应物：
  描述：

  2-Chloromethyl-4-ethoxy-7-hydroxysaccharin 、 1-苯基-1H-四唑-5-硫醇 钠盐 以 乙醇 为溶剂， 反应 8.0h， 以gave 2-(1-phenyltetrazol-5-yl)thiomethyl-4-ethoxy-7-hydroxysaccharin, mp 178°-180° C.的产率得到2-(1-Phenyltetrazol-5-yl)thiomethyl-4-ethoxy-7-hydroxysaccharin
  参考文献：
  名称：

  Saccharin derivatives useful as proteolytic enzyme inhibitors and

  摘要：

  这是一种化合物，可用于治疗退行性疾病，具有抑制蛋白酶酶活性的作用。其化学式为：##STR1## 其中：L为--O--、--S--、--SO--或--SO.sub.2 --；m和n各自独立地为0或1；R.sub.1为卤素、低烷酰基、1-氧代苯并茂、苯基或取代苯基、杂环基或取代杂环基，或当L为--O--且n为1时，为环庚三烯-2-基，或当L为--S--且n为1时，为氰基或低烷氧硫酰基，或当L为--SO.sub.2 --且n为1时，为低烷基或三氟甲基；R.sub.2为氢、低烷氧羰基、苯基或苯基硫；R.sub.3和R.sub.4各自为氢或不同的取代基。该化合物的制备方法、药物组合物及使用方法也被揭示。

  公开号：

  US05650422A1

文献信息

• 2-PYRIDONE COMPOUNDS
  申请人：KAWAGUCHI Takanori

  公开号：US20110237791A1

  公开（公告）日：2011-09-29

  A 2-pyridone compound represented by the formula [1]: wherein in the formula [1], the ring represented by A represents a benzene ring or a pyridine ring, X represents any of the structures represented by the formulas [3] shown below: V represents a single bond or a lower alkylene group, and W represents a single bond, an ether bond or a lower alkylene group (wherein the lower alkylene group may contain an ether bond)}, a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is a compound that has an excellent GK activating effect and is useful as a pharmaceutical.

  化学式为[1]所代表的2-吡啶酮化合物： 其中在化学式[1]中， 由A代表苯环或吡啶环表示的环， X代表下面所示的化学式[3]所代表的任意结构： V代表单键或较低的烷基链，以及 W代表单键、醚键或较低的烷基链（其中较低的烷基链可能含有醚键）}， 该化合物的异构体或立体异构体，其药学上可接受的盐，或其溶剂化合物是一种具有出色的GK激活效果并且可用作药物的化合物。
• Saccharin derivative proteolytic enzyme inhibitors
  申请人：Sterling Winthrop Inc.

  公开号：US05380737A1

  公开（公告）日：1995-01-10

  Compounds having the structural formula ##STR1## wherein L is N, O or SO.sub.n wherein n is 0, 1 or 2; L-R.sup.1 is a leaving group, H-L-R.sup.1 is the conjugate acid thereof and, when L is N, H-L-R.sup.1 has a pK.sub.a value less than or equal to 6, when L is O, H-L-R.sup.1 has a pK.sub.a value less than or equal to to 8, and when L is SO.sub.n, H-L-R.sup.1 has a pK.sub.a value less than or equal to 5; R.sup.2 is primary or secondary alkyl of two to four carbon atoms, primary alkylamino of one to three carbon atoms, primary alkylmethylamino of two to four carbon atoms, diethylamino or primary alkoxy of one to three carbon atoms; and R.sup.3 is from one to three of a variety of substituents at any or all of the 5-, 6- and 7-positions; or a pharmaceutically acceptable acid addition salt thereof if the compound has a basic functional group or a pharmaceutically acceptable base addition salt thereof if the compound has an acidic functional group, which inhibit the enzymatic activity of proteolytic enzymes, and processes for preparation thereof, method of use thereof in treatment of degenerative diseases and pharmaceutical compositions thereof are disclosed.

  本发明涉及结构式##STR1##的化合物，其中L为N，O或SO.sub.n，其中n为0、1或2；L-R.sup.1为离去基团，H-L-R.sup.1为其共轭酸，当L为N时，H-L-R.sup.1的pK.sub.a值小于或等于6，当L为O时，H-L-R.sup.1的pK.sub.a值小于或等于8，当L为SO.sub.n时，H-L-R.sup.1的pK.sub.a值小于或等于5；R.sup.2为二到四个碳原子的一级或二级烷基，一到三个碳原子的一级烷基氨基，二到四个碳原子的一级烷基甲基氨基，二乙基氨基或一到三个碳原子的一级烷氧基；R.sup.3为在5-、6-和7-位置的各种取代基中的一到三个；或其药学上可接受的酸加成盐，如果化合物具有碱性官能团，或其药学上可接受的碱加成盐，如果化合物具有酸性官能团，其抑制蛋白酶酶活性，公开了其制备方法，治疗退行性疾病的使用方法和其制药组合物。
• 2-pyridone compounds
  申请人：Kawaguchi Takanori

  公开号：US08822503B2

  公开（公告）日：2014-09-02

  A 2-pyridone compound represented by the formula [1]: wherein in the formula [1], the ring represented by A represents a benzene ring or a pyridine ring, X represents any of the structures represented by the formulas [3] shown below: V represents a single bond or a lower alkylene group, and W represents a single bond, an ether bond or a lower alkylene group (wherein the lower alkylene group may contain an ether bond)}, a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is a compound that has an excellent GK activating effect and is useful as a pharmaceutical.

  式[1]所表示的2-吡啶酮化合物：在式[1]中，由A表示的环代表苯环或吡啶环，X表示下列式[3]所表示的任何结构：V代表单键或较低的烷基烯基，W代表单键、醚键或较低的烷基烯基（其中较低的烷基烯基可能包含醚键）}，该化合物的互变异构体或立体异构体、其药学上可接受的盐或其溶剂化物是一种具有极佳的GK激活作用并可用作药物的化合物。
• Diffusion transfer material
  申请人：AGFA-GEVAERT naamloze vennootschap

  公开号：EP0089069A1

  公开（公告）日：1983-09-21

  A photographic silver halide material comprising a compound which is capable of being reduced by a silver halide developing agent at a rate slower than that of image-wise developable silver halide and in reduced state is capable of releasing a photographically useful group, characterized in that said compound corresponds to the following formula : wherein : R10 and R20 (same or different) (1) represent an alkyl group, a cycloalkyl group, an alkenyl group, a cycloalkenyl group or an aralkyl group including said groups in substituted form, (2) represent an aryl group including a substituted aryl group, or (3) represent a heterocyclic ring residue including such residue in substituted form or R'° and R20 are ringclosed, either R'° or R20 containing a ballasting group conferring diffusion resistance to the com- pond in hydrophilic colloid media when penetrated by an aqueous alkaline liquid; L' and L2 (same or different) represent a NHCO-: group; p and q (same or different) represent an integer 0 or 1; Z represents an atom or an atom group which is electronegative with respect to carbon, and PUG represents together with Z a releasable photographically useful group.

  一种摄影用卤化银材料，由一种化合物组成，该化合物能被卤化银显影剂还原，还原速度慢于图像显影用卤化银的还原速度，并且在还原状态下能释放出对摄影有用的基团，其特征在于所述化合物符合下式： 其中 ： R10 和 R20（相同或不同） (1) 代表烷基、环烷基、烯基、环烯基或芳基，包括上述取代形式的基团、 (2) 代表芳基，包括取代的芳基，或 (3) 代表杂环残基，包括取代形式的杂环残基，或 R'° 和 R20 是闭环的，其中任一 R'° 或 R20 含有一个压载基团，当被水性碱性液体渗透时，可使组合物在亲水性胶体介质中具有抗扩散性； L' 和 L2（相同或不同）代表一个 NHCO-： 基团； p 和 q（相同或不同）代表整数 0 或 1； Z 代表相对于碳呈电负性的原子或原子团，以及 PUG 与 Z 一起代表可释放的摄影用基团。
• Stabilization of developed electrophoregrams
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0192463A2

  公开（公告）日：1986-08-27

  A method for determining macromolecules in polyacrylamide gels comprising the steps of forming a latent stain image by nucleating the macromolecules in the gel with a palladium tetraamine salt and developing the latent stain image by treating the gel with a physical developing solution comprising dimethylamine borane and a transition metal salt a tetrazolium salt or a triazolium salt, characterized by the step of stabilizing the developed latent stain image by contacting the gel with a 1-phenyl-2-tetrazoline-5-thione or a salt of 1-phenyl-1H-tetrazole-5-thiol.

  一种测定聚丙烯酰胺凝胶中大分子的方法，包括以下步骤：用四胺钯盐使凝胶中的大分子成核，形成潜染图像；用由二甲胺硼烷和过渡金属盐（四唑盐或三唑盐）组成的物理显影液处理凝胶，显影潜染图像，其特征在于用1-苯基-2-四唑啉-5-硫酮或1-苯基-1H-四唑-5-硫醇的盐接触凝胶，稳定显影的潜染图像。