1-para-anisyl-8,9-dimethoxy-5-methyl-3-phenyl-5,6-dihydro-4H-pyrazolo<3,4-c>benzoazepin-4-one | 143739-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-para-anisyl-8,9-dimethoxy-5-methyl-3-phenyl-5,6-dihydro-4H-pyrazolo<3,4-c>benzoazepin-4-one
• 英文别名: 8,9-dimethoxy-1-(4-methoxyphenyl)-5-methyl-3-phenyl-6H-pyrazolo[3,4-d][2]benzazepin-4-one
• CAS: 143739-67-7
• 化学式: C₂₇H₂₅N₃O₄
• 分子量: 455.513
• InChiKey: HAENBJHIQFSEJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  65.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  iodure de 6,7-dimethoxy-3-ethoxycarbonyl-N-methylisoquinolinium 在 氢氧化钾 、 sodium tetrahydroborate 、 三乙胺 作用下， 以 甲醇 、 乙醇 、 水 、 苯 为溶剂， 反应 29.0h， 生成 1-para-anisyl-8,9-dimethoxy-5-methyl-3-phenyl-5,6-dihydro-4H-pyrazolo<3,4-c>benzoazepin-4-one
  参考文献：
  名称：

  Moustaid, Khadija; An, Nguyen Dinh; Laude, Bernard, Canadian Journal of Chemistry, 1992, vol. 70, # 3, p. 802 - 808

  摘要：

  DOI：

文献信息

• SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF GROUP II METABOTROPIC GLUTAMATE RECEPTORS
  申请人：Mavalon Therapeutics Limited

  公开号：US20200140438A1

  公开（公告）日：2020-05-07

  The present invention provides novel heterocyclic compounds of the general formula (I), including novel compounds of formula (Ia), and pharmaceutical compositions containing them. Moreover, the compounds of formula (I) or (Ia) and the pharmaceutical compositions containing them are provided for use in the treatment and/or prophylaxis of conditions associated with altered glutamatergic signalling and/or functions, and/or conditions which can be affected by alteration of glutamate level or signalling in mammals. The compounds of formula (I) or (Ia) can act as modulators of nervous system receptors sensitive to glutamate, in particular as modulators of metabotropic glutamate receptors (mGluRs), which makes them particularly suitable for the treatment and/or prophylaxis of acute and chronic neurological and/or psychiatric disorders. The present invention further provides compounds of formula (I) or (Ia) that are modulators of metabotropic glutamate receptors (mGluRs), particularly positive allosteric modulators of mGluRs, and more specifically positive allosteric modulators of mGluR3.