2-(4-(2-morpholinoethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenol | 1380243-91-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-(2-morpholinoethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenol
• 英文别名: 2-[4-(2-Morpholin-4-yl-ethyl)-4,5,6,7-tetrahydro-indazol-1-yl]-phenol；2-[4-(2-Morpholin-4-ylethyl)-4,5,6,7-tetrahydroindazol-1-yl]phenol
• CAS: 1380243-91-3
• 化学式: C₁₉H₂₅N₃O₂
• 分子量: 327.426
• InChiKey: GODIHMVDJXAZER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  50.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 2-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-YL)ethylamine derivatives useful as sigma receptor inhibitors
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2468728A1

  公开（公告）日：2012-06-27

  The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to indazole derivatives of formula I and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and/or prophylaxis, in particular for the treatment of psychosis or pain.

  本发明涉及具有对sigma受体的药理活性的化合物，更具体地涉及公式I的吲唑衍生物及其制备过程，包括含有它们的制药组合物，以及它们在治疗和/或预防中的使用，特别是用于治疗精神病或疼痛。
• STABLE HELICAL IONIC POLYPEPTIDES
  申请人：The Board of Trustees of the University of Illinois

  公开号：EP2646048A2

  公开（公告）日：2013-10-09
• [EN] 2-(1-PHENYL-4,5,6,7-TETRAHYDRO-1H-INDAZOL-4-YL)ETHYLAMINE DERIVATIVES USEFUL AS SIGMA RECEPTOR INHIBITORS<br/>[FR] DÉRIVÉS DE 2-(1-PHÉNYL-4,5,6,7-TÉTRAHYDRO-1H-INDAZOL-4-YL)ÉTHYLAMINE UTILES EN TANT QU'INHIBITEURS DES RÉCEPTEURS SIGMA
  申请人：ESTEVE LABOR DR

  公开号：WO2012072791A2

  公开（公告）日：2012-06-07

  The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to indazole derivatives of formula I and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and/or prophylaxis, in particular for the treatment of psychosis or pain.
• [EN] STABLE HELICAL IONIC POLYPEPTIDES<br/>[FR] POLYPEPTIDES IONIQUES HÉLICOÏDAUX STABLES
  申请人：UNIV ILLINOIS

  公开号：WO2012075147A2

  公开（公告）日：2012-06-07

  The invention provides polymers comprising Formula 1 wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally substituted carbon chain that is optionally interrupted by moieties such as oxygen, nitrogen, sulfur, phosphorus, or silicon. Charge is a moiety having a positive or negative charge on a heteroatom, such as nitrogen, oxygen, phosphorus, or sulfur; where the Linker separates the monomer and the Charge by at least six linear atoms. The invention also provides methods of preparing the polymers and the copolymers and methods of using the polymers and copolymers, for example, as drug delivery systems, as membrane penetrating peptides, and as therapeutic agents.