N-(N-benzyloxycarbonyl-L-tyrosyl)-L-tyrosine hexyl ester | 106231-84-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(N-benzyloxycarbonyl-L-tyrosyl)-L-tyrosine hexyl ester
• 英文别名: n-Benzyloxycarbonyl-l-tyrosyl-l-tyrosine hexyl ester；hexyl (2S)-3-(4-hydroxyphenyl)-2-[[(2S)-3-(4-hydroxyphenyl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoate
• CAS: 106231-84-9
• 化学式: C₃₂H₃₈N₂O₇
• 分子量: 562.663
• InChiKey: ZLYDMRSEDCRVQO-VMPREFPWSA-N

物化性质

• 沸点：
  799.0±60.0 °C(Predicted)
• 密度：
  1.220±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  41
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  溴化氰 、 N-(N-benzyloxycarbonyl-L-tyrosyl)-L-tyrosine hexyl ester 以 乙酸乙酯 为溶剂， 以78%的产率得到L-酪氨酸,N-[O-氰基-N-[(苯基甲氧基)羰基]-L-酪氨酰]-,己基酯,氰酸酯(ester)
  参考文献：
  名称：

  涉及α-L-氨基酸侧链的聚合反应

  摘要：

  Faisabilite de lapolymerisation de cesaminoacids naturalls via leurs chaineslaterales par des liaisons autres que les liaisons amide

  DOI：

  10.1021/ja00237a030
• 作为产物：
  描述：

  L-酪氨酸 在 氯化亚砜 、 聚碳化二亚胺 作用下， 反应 12.0h， 生成 N-(N-benzyloxycarbonyl-L-tyrosyl)-L-tyrosine hexyl ester
  参考文献：
  名称：

  涉及α-L-氨基酸侧链的聚合反应

  摘要：

  Faisabilite de lapolymerisation de cesaminoacids naturalls via leurs chaineslaterales par des liaisons autres que les liaisons amide

  DOI：

  10.1021/ja00237a030

文献信息

• Degradable aliphatic-aromatic block polyester carbonates and their preparation
  申请人：MITSUI TOATSU CHEMICALS, INCORPORATED

  公开号：EP0778306A2

  公开（公告）日：1997-06-11

  A degradable copolymer obtained by heat-dehydration reaction of aromatic polycarbonate and aliphatic polyester in the presence of a catalyst, has degradability which cannot be exhibited by common aromatic polycarbonate, transparency equal to polycarbonate, thermal resistance which cannot be exhibited by common aliphatic polyester, melt flowability superior to common aromatic polycarbonate and other excellent characteristics, and thus can be widely used for processed articles which require severe properties.

  芳香族聚碳酸酯和脂肪族聚酯在催化剂存在下通过热脱水反应得到的可降解共聚物，具有普通芳香族聚碳酸酯所不具备的可降解性、与聚碳酸酯相同的透明度、普通脂肪族聚酯所不具备的耐热性、优于普通芳香族聚碳酸酯的熔体流动性以及其他优异特性，因此可广泛用于对性能要求苛刻的加工物品。
• Self antigen vaccines for treating B cell lymphomas and other cancers
  申请人：——

  公开号：US20030044417A1

  公开（公告）日：2003-03-06

  A polypeptide self-antigen useful in a tumor-specific vaccine mimics one or more epitopes of an antigen uniquely expressed by cells of the tumor. The polypeptide is preferably produced in a plant that has been transformed or transfected with nucleic acid encoding the polypeptide and is obtainable from the plant in correctly folded, preferably soluble form without a need for denaturation and renaturation. This plant-produced polypeptide is immunogenic without a need for exogenous adjuvants or other immunostimulatory materials. The polypeptide is preferably an scFv molecule that bears the idiotype of the surface immunoglobulin of a non-Hodgkin's (or B cell) lymphoma. Upon administration to a subject with lymphoma, the plant-produced, tumor-unique scFv polypeptide induces an idiotype-specific antibody or cell-mediated immune response against the lymphoma.

  用于肿瘤特异性疫苗的多肽自身抗原可模拟肿瘤细胞独特表达的抗原的一个或多个表位。这种多肽最好是在植物中生产的，这种植物已被编码该多肽的核酸转化或转染，可从植物中获得正确折叠的、最好是可溶的形式，无需变性和再变性。这种植物生产的多肽具有免疫原性，无需外源佐剂或其他免疫刺激材料。多肽最好是带有非霍奇金淋巴瘤（或 B 细胞）表面免疫球蛋白特异型的 scFv 分子。给淋巴瘤患者用药后，植物生产的肿瘤特有 scFv 多肽可诱导针对淋巴瘤的特异性抗体或细胞介导的免疫反应。
• Mid-life vaccine and methods for boosting anti-mycobacterial immunity
  申请人：——

  公开号：US20040180056A1

  公开（公告）日：2004-09-16

  Vaccine compositions for boosting immunity to mycobacteria when administered in mid-life in a subject who has been vaccinated neonatally or in early childhood with BCG and in whom protective immunity has waned comprise one or more purified immunogenic proteins from Mycobacterium tuberculosis from a group of 30 proteins that stimulate T cell immunity and interferon-&ggr; secretion. A preferred protein is Ag85A, the secreted product (SEQ ID NO:31) of the Rv3084c gene. Also disclosed are methods for boosting immunity in such BCG-vaccinated subjects comprising administering an effective amount of the above vaccine composition.

  在新生儿期或幼儿期接种卡介苗后，保护性免疫力减弱的受试者在中年期接种疫苗时，用于增强对分枝杆菌的免疫力的疫苗组合物包含一种或多种纯化的免疫原蛋白，这些蛋白来自于 结核分枝杆菌 从一组 30 种可刺激 T 细胞免疫和干扰素&ggr; 分泌的蛋白质中提取。一种优选的蛋白质是 Ag85A，它是 Rv3084c 基因的分泌产物（SEQ ID NO:31）。还公开了增强接种过卡介苗的受试者免疫力的方法，包括施用有效量的上述疫苗组合物。
• Poly(ester amide) block copolymers
  申请人：Hossainy Faiyaz Ahmed Syed

  公开号：US20060142541A1

  公开（公告）日：2006-06-29

  Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the relative amount of the PEA block and the hard block, one can obtain a copolymer with a T g for mechanical integrity in drug-delivery stent applications. The copolymer can be used alone or optionally in combination with a biobeneficial material and/or a biocompatible polymer to form an implantable device or a coating on an implantable device. When the copolymer is used in combination with a biobeneficial material, the copolymer and the biobeneficial material can be co-deposited or applied in sequence during the coating process. A coating formed of the copolymer may also include a bioactive agent. The implantable device can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, and/or tumor obstruction.

  本文提供的共聚物包括含有聚（酯酰胺）（PEA）的软嵌段（A）和硬嵌段（B）。该共聚物可以是 AB、ABA 或 BAB 型嵌段共聚物中的任何一种。通过改变 PEA 嵌段和硬嵌段的相对含量，可以得到一种共聚物，其 T g 的共聚物，以满足给药支架应用中的机械完整性要求。共聚物可单独使用，也可与生物有益材料和/或生物相容性聚合物结合使用，以形成植入装置或植入装置涂层。当共聚物与生物益性材料结合使用时，共聚物和生物益性材料可在涂层过程中依次共同沉积或应用。由共聚物形成的涂层还可包括生物活性剂。可植入装置可植入患者体内，以治疗、预防或改善动脉粥样硬化、血栓形成、血管再狭窄、出血、血管剥离或穿孔、血管动脉瘤、易损斑块、慢性全闭塞、跛行、静脉和人工移植物吻合口增生、胆管阻塞、输尿管阻塞和/或肿瘤阻塞等疾病。
• SELF ANTIGEN VACCINES FOR TREATING B CELL LYMPHOMAS AND OTHER CANCERS
  申请人：Large Scale Biology Corporation

  公开号：EP1263779A1

  公开（公告）日：2002-12-11