2-Acetoxy-3-brommethyl-benzoesaeure-methylester | 13339-09-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Acetoxy-3-brommethyl-benzoesaeure-methylester
• 英文别名: Methyl 2-acetyloxy-3-(bromomethyl)benzoate
• CAS: 13339-09-8
• 化学式: C₁₁H₁₁BrO₄
• 分子量: 287.11
• InChiKey: WIPFFGDATNUNSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Acetoxy-3-brommethyl-benzoesaeure-methylester 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 、 苯 为溶剂， 反应 50.0h， 生成 methyl 2-methylbenzofuran-7-carboxylate
  参考文献：
  名称：

  Synthesis of fluorovinylsalicylic acids and their derivatives

  摘要：

  Palladium-catalyzed cross-coupling of iodosalicylic acid derivatives with polfluorovinyl zinc reagents provided the corresponding fluorovinyl-substituted salicylates. Methyl-5-(beta,beta)-difluorovinyl methyl salicylate was prepared by a Wittig reaction of the 5-formyl compound with the strongly nucleophilic ylide, [(Et(2)N)(3)P-CF2]. In one sequence, a fluorine-free benzofuran was obtained, instead of a difluorovinyl-salicylate.

  DOI：

  10.1016/0022-1139(95)03255-c
• 作为产物：
  描述：

  3-甲基水杨酸 在 N-溴代丁二酰亚胺(NBS) 、 过氧化氢苯甲酰 、 硫酸 作用下， 以 四氯化碳 为溶剂， 反应 85.0h， 生成 2-Acetoxy-3-brommethyl-benzoesaeure-methylester
  参考文献：
  名称：

  Synthesis of fluorovinylsalicylic acids and their derivatives

  摘要：

  Palladium-catalyzed cross-coupling of iodosalicylic acid derivatives with polfluorovinyl zinc reagents provided the corresponding fluorovinyl-substituted salicylates. Methyl-5-(beta,beta)-difluorovinyl methyl salicylate was prepared by a Wittig reaction of the 5-formyl compound with the strongly nucleophilic ylide, [(Et(2)N)(3)P-CF2]. In one sequence, a fluorine-free benzofuran was obtained, instead of a difluorovinyl-salicylate.

  DOI：

  10.1016/0022-1139(95)03255-c

文献信息

• COMPOUNDS FOR SEPARATION OF RARE EARTH ELEMENTS, METHOD OF SEPARATION, AND USE THEREOF
  申请人：Ustav organicke chemie a biochemie AV CR, v.v.i.

  公开号：EP3492460A1

  公开（公告）日：2019-06-05

  The present invention relates to the use of the compounds of general formula (I): wherein X, Y, Z, L, R and R1 are as described herein; for chromatographic separation of rare earth elements, as well as to the method of the separation of rare earth elements.

  本发明涉及通式（I）化合物的用途： 其中 X、Y、Z、L、R 和 R1 如本文所述； 以及分离稀土元素的方法。
• [EN] LIGANDS OF ADENINE NUCLEOTIDE TRANSLOCASE (ANT) AND COMPOSITIONS AND METHODS RELATED THERETO<br/>[FR] LIGANDS D'ADENINE NUCLEOTIDE TRANSLOCASE (ANT) ET COMPOSITIONS ET METHODES ASSOCIEES
  申请人：MITOKOR INC

  公开号：WO2004058679A3

  公开（公告）日：2004-08-26
• Tricyclic heterocycles
  申请人：ZENECA LIMITED

  公开号：EP0480641B1

  公开（公告）日：1995-04-05
• Benzopyranones with retro-amide side chains as (inhibitory) β-lactamase substrates
  作者：S.A. Adediran、D. Cabaret、J.-F. Lohier、M. Wakselman、R.F. Pratt

  DOI：10.1016/j.bmcl.2004.07.067

  日期：2004.10

  3-(N-Benzylcarbamoyl)-7-carboxy-3, 4-dihydro-2H-1-benzo-pyran-2-one and its 8-carboxy analogue have been synthesized and evaluated as potential (inhibitory) substrates of beta-lactam-recognizing enzymes. These compounds are bicyclic delta-lactones with retro-amide (with respect to classical beta-lactams) side chains. They were found to be comparably effective as substrates of typical class A, C and D beta-lactamases as analogous benzopyranones bearing 'normal' amide side chains. The new 8-carboxy derivative, however, formed a much more (1000-fold) tightly-bound acyl-enzyme with a class C beta-lactamase than did its 'normal' analogue, and thus provides a structural lead to new inhibitors of this class of beta-lactamase. (C) 2004 Elsevier Ltd. All rights reserved.
• COMPOUNDS FOR SEPARATION OF RARE EARTH ELEMENTS AND S-, P-, D- METALS, METHOD OF SEPARATION, AND USE THEREOF
  申请人：Ustav Organicke Chemie a Biochemie AV CR, v.v.i.

  公开号：EP3717466A1

  公开（公告）日：2020-10-07