1-(4-methoxyphenyl)-3-phenyl-3-(phenylamino)propan-1-one | 1091601-94-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(4-methoxyphenyl)-3-phenyl-3-(phenylamino)propan-1-one
• 英文别名: (3R)-3-anilino-1-(4-methoxyphenyl)-3-phenylpropan-1-one
• CAS: 1091601-94-3
• 化学式: C₂₂H₂₁NO₂
• 分子量: 331.414
• InChiKey: OTJZOJJFBIXHRX-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2E)-1-(4-甲氧基苯基)-3-苯基-2-丙烯-1-酮 、 苯胺 在 8R,9S-cinchoine 作用下， 反应 24.0h， 以45%的产率得到1-(4-methoxyphenyl)-3-phenyl-3-(phenylamino)propan-1-one
  参考文献：
  名称：

  Organocatalytic asymmetric aza-Michael addition of aniline to chalcones under solvent-free conditions

  摘要：

  The first enantioselective Michael addition of aniline to chalcones was promoted by cheap and commercially available chincona alkaloids under solvent-free conditions. Variously substituted chalcones were examined as substrates giving the conjugate adducts in moderate to good enantioselectivity. The simple experimental procedure had no work-up and short reaction times, which are the notable advantages. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.09.006