{5-[({1-[4-(3,5-dimethyl-pyrazol-1-ylmethyl)-benzyl]-1H-pyrazole-4-carbonyl}-amino)-methyl]-4,6-dimethyl-pyridin-2-yl}-carbamic acid tert-butyl ester | 1357956-73-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: {5-[({1-[4-(3,5-dimethyl-pyrazol-1-ylmethyl)-benzyl]-1H-pyrazole-4-carbonyl}-amino)-methyl]-4,6-dimethyl-pyridin-2-yl}-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[5-[[[1-[[4-[(3,5-dimethylpyrazol-1-yl)methyl]phenyl]methyl]pyrazole-4-carbonyl]amino]methyl]-4,6-dimethylpyridin-2-yl]carbamate
• CAS: 1357956-73-0
• 化学式: C₃₀H₃₇N₇O₃
• 分子量: 543.669
• InChiKey: CJWGWUPRKUDVGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES
  申请人：BRANDL Trixi

  公开号：US20120035168A1

  公开（公告）日：2012-02-09

  The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.

  本发明涉及具有公式I的化合物，其中取代基如说明书中所定义；以自由形式或盐形式存在；及其制备方法，作为药品的使用，以及包含它的药品。
• N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES AS INHIBITORS OF PLASMA KALLIKREIN
  申请人：Novartis AG

  公开号：EP2601189B1

  公开（公告）日：2015-04-15
• US9290485B2
  申请人：——

  公开号：US9290485B2

  公开（公告）日：2016-03-22
• [EN] N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES AS INHIBITORS OF PLASMA KALLIKREIN<br/>[FR] N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES UTILISÉS COMME INHIBITEURS DE LA KALLICRÉINE PLASMATIQUE
  申请人：NOVARTIS AG

  公开号：WO2012017020A1

  公开（公告）日：2012-02-09

  The invention relates to compound of the formula (I) in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.