3,3-dimethyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-yl}amide) | 1260490-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,3-dimethyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-yl}amide)
• 英文别名: 3,3-dimethyl-1-N-[4-methyl-5-[2-(1-methylcyclopropyl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
• CAS: 1260490-99-0
• 化学式: C₂₁H₂₇N₅O₂S
• 分子量: 413.544
• InChiKey: NWHXXPWMNPOCSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Substituted 2-Carboxamide Cycloamino Ureas
  申请人：Fairhurst Robin Alec

  公开号：US20110003818A1

  公开（公告）日：2011-01-06

  The present invention relates to compounds of formula I and salts thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameliorated by inhibition of phosphatidylinositol 3-kinase.

  本发明涉及公式I的化合物及其盐，其中取代基如描述中所定义，以及这些化合物在治疗通过抑制磷脂酰肌醇3-激酶改善的疾病中的应用。
• US8293753B2
  申请人：——

  公开号：US8293753B2

  公开（公告）日：2012-10-23
• [EN] SUBSTITUTED 2-CARBOXAMIDE CYCLOAMINO UREAS<br/>[FR] 2-CARBOXAMIDE CYCLOAMINO URÉES SUBSTITUÉES
  申请人：NOVARTIS AG

  公开号：WO2011000905A1

  公开（公告）日：2011-01-06

  The present invention relates to compounds of formula (I), and salts thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.