25,26,27,28-Tetrakis(ethoxyethoxy)-5,11,17,23-tetranitrocalix<4>arene | 137571-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 25,26,27,28-Tetrakis(ethoxyethoxy)-5,11,17,23-tetranitrocalix<4>arene
• 英文别名: Tetrakis(ethoxyethoxy)tetranitrocalix<4>arene；5,11,17,23-Tetranitro-25,26,27,28-tetrakis(2-ethoxyethoxy)calix<4>aren；25,26,27,28-Tetrakis(2-ethoxyethoxy)-5,11,17,23-tetranitropentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaene
• CAS: 137571-06-3
• 化学式: C₄₄H₅₂N₄O₁₆
• 分子量: 892.914
• InChiKey: FLVWVNHTVUQBBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  64
• 可旋转键数：
  20
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  257
• 氢给体数：
  0
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  25,26,27,28-Tetrakis(ethoxyethoxy)-5,11,17,23-tetranitrocalix<4>arene 在 sodium tetrahydroborate 作用下， 以 甲醇 、 氯仿 为溶剂， 生成
  参考文献：
  名称：

  Scheerder, Jurgen; Duynhoven, John P. M. van; Engbersen, Johan F. J., Angewandte Chemie, 1996, vol. 108, # 10, p. 1172 - 1175

  摘要：

  DOI：
• 作为产物：
  描述：

  5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis(2-ethoxyethoxy)calix[4]arene 在 硝酸 作用下， 以 二氯甲烷 、 溶剂黄146 为溶剂， 反应 1.0h， 以76%的产率得到25,26,27,28-Tetrakis(ethoxyethoxy)-5,11,17,23-tetranitrocalix<4>arene
  参考文献：
  名称：

  Ipso nitration of p-tert-butylcalix[4]arenes

  摘要：

  DOI：

  10.1021/jo00030a050

文献信息

• Upper Rim Guanidinocalix[4]arenes as Artificial Phosphodiesterases
  作者：Laura Baldini、Roberta Cacciapaglia、Alessandro Casnati、Luigi Mandolini、Riccardo Salvio、Francesco Sansone、Rocco Ungaro

  DOI：10.1021/jo300193y

  日期：2012.4.6

  Calix[4]arene derivatives, blocked in the cone conformation and functionalized with two to four guanidinium units at the upper rim were synthesized and investigated as catalysts in the cleavage of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate. When compared with the behavior of a monofunctional model compound, the catalytic superiority of the calix[4]arene derivatives points to a high level of cooperation between catalytic groups. Combination of acidity measurements with the pH dependence of catalytic rates unequivocally shows that a necessary requisite for effective catalysis is the simultaneous presence, on the same molecular framework, of a neutral guanidine acting as a general base and a protonated guanidine acting as an electrophilic activator. The additional guanidinium (guanidine) group in the diprotonated (monoprotonated) trifunctional calix[4]arene acts as a more or less innocent spectator. This is not the case with the tetrasubstituted calix[4]arene, whose mono-, di-, and triprotonated forms are slightly less effective than the corresponding di- and triguanidinocalix[4]arene derivatives, most likely on account of a steric interference with HPNP caused by overcrowding.
• Yang, Xiaoguang; McBranch, Duncan; Swanson, Basil, Angewandte Chemie, 1996, vol. 108, # 5, p. 572 - 575
  作者：Yang, Xiaoguang、McBranch, Duncan、Swanson, Basil、Li, DeQuan

  DOI：——

  日期：——