2-(4-methoxyphenyl)-3,4,5-triphenyl-1H-pyrrole | 22394-06-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-(4-methoxyphenyl)-3,4,5-triphenyl-1H-pyrrole
• 英文别名: 2-(p-Methoxyphenyl)-3,4,5-triphenylpyrrol；2-(4-methoxy-phenyl)-3,4,5-triphenyl-pyrrole
• CAS: 22394-06-5
• 化学式: C₂₉H₂₃NO
• 分子量: 401.508
• InChiKey: HKSVGFSXGMKMAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  25
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-甲氧基-2-苯基苯乙酮 、 安息香精油 在 ammonium acetate 、 溶剂黄146 作用下， 反应 12.0h， 以91%的产率得到2-(4-methoxyphenyl)-3,4,5-triphenyl-1H-pyrrole
  参考文献：
  名称：

  Acid-Promoted Cross-Dehydrative Aromatization for the Synthesis of Tetraaryl-Substituted Pyrroles

  摘要：

  Tetraaryl-substituted pyrroles are one important class of luminophores. In this work, an acid-promoted cross-dehydrative aromatization between benzoin and deoxybenzion was developed. This transformation provides an efficient and straightforward path for the synthesis of various aryl group substituted tetraarylpyrroles. Good to excellent yields were obtained through the easy operation with acetic acid and ammonium acetate.

  DOI：

  10.1021/acs.orglett.5b03240

文献信息

• Palladium/Silver Cocatalyzed Divergent Dimerization of 2<i>H</i>-Azirines for Regioselective Synthesis of Tetrasubstituted Pyrroles and Pyrimidines
  作者：Yongxing Zhao、Rui Li、Qingzheng Zhao、Jinzhong Yao、Maozhong Miao

  DOI：10.1021/acs.orglett.3c01434

  日期：2023.6.2

  The unprecedented dimerizations of 2H-azirines have been developed under the catalysis of palladium and silver. Upon changing the reaction conditions, the fully aryl-substituted pyrrole and pyrimidine derivatives were furnished in moderate yields with regiospecificity, respectively. Control experiments uncovered distinct catalytic effects of two transition metals, and the proposed catalytic cycles

  在钯和银的催化下，2 H -azirines 的前所未有的二聚化已经发展起来。在改变反应条件后，完全芳基取代的吡咯和嘧啶衍生物分别以中等产率和区域特异性提供。对照实验揭示了两种过渡金属的不同催化作用，所提出的催化循环似乎合理化了化学发散和区域​​选择性。