1-Amino-trans-4-methyl-cyclohexan-carbonsaeure | 32958-45-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Amino-trans-4-methyl-cyclohexan-carbonsaeure
• CAS: 32958-45-5
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: YUYUWXWDMRXHHN-WRXNHJIOSA-N

物化性质

• 熔点：
  305-310 °C(Solv: acetic acid (64-19-7); water (7732-18-5))
• 沸点：
  276.4±23.0 °C(Predicted)
• 密度：
  1.086±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  1-Amino-trans-4-methyl-cyclohexan-carbonsaeure 在 lithium aluminium tetrahydride 、 sodium carbonate 作用下， 以 四氢呋喃 为溶剂， 以65.86 %的产率得到((1s,4s)-1-amino-4-methylcyclohexyl)methanol
  参考文献：
  名称：

  [EN] 4-HYDROXY-2-OXO-1,2-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXAMIDE DERIVATIVES AS CANNABINOID CB2 RECEPTOR MODULATORS FOR THE TREATMENT OF CANCER
  [FR] DÉRIVÉS DE 4-HYDROXY-2-OXO-1,2-DIHYDRO-1,8-NAPHTYRIDINE-3-CARBOXAMIDE UTILISÉS EN TANT QUE MODULATEURS DU RÉCEPTEUR CB2 CANNABINOÏDE POUR LE TRAITEMENT DU CANCER

  摘要：

  The present invention relates to 82 specific 4-hydroxy-2-oxo-1,2- dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid CB2 receptor modulators for the treatment of cancer, e.g. to 6-(4- fluorophenyl)-4-hydroxy-1-(2-(4-methylpiperazin-1-yl)ethyl)-2-oxo-N- (spiro[2.3]hexan-5-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamide (example 1, compound 1) The present description discloses the synthesis and characterisation of the 82 claimed compounds as well as biological assays thereof.

  公开号：

  WO2023081730A1

文献信息

• Cis-Alkoxyspiro-Substituted Tetramic Acid Derivatives
  申请人：Fischer Reiner

  公开号：US20070244007A1

  公开（公告）日：2007-10-18

  The invention relates to novel cis-alkoxyspiro-substituted tetramic acid derivatives of the formula (I), in which A, G, X, Y and Z are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising firstly cis-alkoxyspiro-substituted tetramic acid derivatives and secondly a crop plant compatibility-improving compound.

  该发明涉及新型的顺式烷氧基螺环取代四酮酸衍生物的公式(I)，其中A、G、X、Y和Z如上所定义，以及其制备的多种过程和中间体，以及它们作为杀虫剂和/或除草剂的用途，还涉及包括首先顺式烷氧基螺环取代四酮酸衍生物和其次是一种改善作物植物兼容性的化合物的选择性除草剂组合物。