| 1592771-26-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1592771-26-0
• 化学式: C₃₈H₄₄O₅Si
• 分子量: 608.85
• InChiKey: KENNKXJRRPMUGG-HKIDPNTFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.48
• 重原子数：
  44.0
• 可旋转键数：
  13.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  53.99
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  在 2,6-二甲基吡啶 、 盐酸 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 为溶剂， 反应 22.33h， 生成 [(2R,3S,5R,6S)-3-methyl-5-phenylmethoxy-6-(2-phenylmethoxyethyl)-3-trimethylsilyloxyoxan-2-yl]methyl trifluoromethanesulfonate
  参考文献：
  名称：

  Synthesis of the KLMN Fragment of Gymnocin-A Using Oxiranyl Anion Convergent Methodology

  摘要：

  Synthesis of the KLMN fragment of gymnocin-A has been achieved by a [X + 2 + Y]-type convergent strategy involving the coupling of a K-ring triflate and an N-ring epoxy sulfone. Fusions of the L ring and the M ring were carried out by intramolecular S(N)2 substitution of a tertiary alcohol and reductive etherification to furnish the target molecule.

  DOI：

  10.1021/ol500788c
• 作为产物：
  描述：

  (2R,3S,5R,6S)-5-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol 在 咪唑 、 草酰氯 、 二甲基亚砜 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.42h， 生成
  参考文献：
  名称：

  Synthesis of the KLMN Fragment of Gymnocin-A Using Oxiranyl Anion Convergent Methodology

  摘要：

  Synthesis of the KLMN fragment of gymnocin-A has been achieved by a [X + 2 + Y]-type convergent strategy involving the coupling of a K-ring triflate and an N-ring epoxy sulfone. Fusions of the L ring and the M ring were carried out by intramolecular S(N)2 substitution of a tertiary alcohol and reductive etherification to furnish the target molecule.

  DOI：

  10.1021/ol500788c

文献信息

• Stereoinversion of a Tertiary Alcohol on a THP Ring: a Recovery Route to an Intermediate for Gymnocin-A
  作者：Yuji Mori、Takeo Sakai、Kayo Aoyama、Rie Oshima、Kyoko Furukawa

  DOI：10.3987/com-17-s(t)8

  日期：——

  The stereoinversion of a tertiary alcohol on a tetrahydropyran ring was achieved through a five-step sequence including regioselective dehydration, diastereoselective epoxidation and reduction. This approach offers a recovery route from the diastereomer to the desired tertiary alcohol as part of the synthesis of gymnocin-A.