8-[1-(4-Methoxyphenyl)-5-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]-1,4-dioxaspiro[4.5]decan-8-ol | 1224949-79-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 8-[1-(4-Methoxyphenyl)-5-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]-1,4-dioxaspiro[4.5]decan-8-ol
• CAS: 1224949-79-4
• 化学式: C₂₅H₂₅F₃N₂O₄
• 分子量: 474.48
• InChiKey: ZIGYLKMBDSSPSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  65.7
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
  申请人：Morita Yasuhiro

  公开号：US20110201650A1

  公开（公告）日：2011-08-18

  A compound has a strong analgesic action against both nociceptive pain and neuropathic pain and has less side effects, and is medically useful. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof.

  这个化合物对于伤害性疼痛和神经病理性疼痛均有强烈的镇痛作用，并且副作用较少，因此在医学上具有实用价值。该化合物包括以下化合物所代表的环己烷衍生物，或其药学上可接受的盐或前药。
• THERAPEUTIC AGENT AND PREVENTATIVE AGENT FOR ALZHEIMER'S DISEASE
  申请人：Toray Industries, Inc.

  公开号：EP2565184A1

  公开（公告）日：2013-03-06

  An object of the present invention is to provide a therapeutic agent or prophylactic agent for Alzheimer's disease, which has an effect to inhibit or delay the progress of Alzheimer's disease and exhibits a long-lasting therapeutic effect on Alzheimer's disease even when used for a long period of time. The present invention provides a therapeutic agent or prophylactic agent for Alzheimer's disease, said agent comprising as an effective ingredient a cyclohexane derivative exemplified by the formula below, or a pharmaceutically acceptable salt thereof or a prodrug thereof.

  本发明的目的是提供一种阿尔茨海默病的治疗剂或预防剂，该治疗剂或预防剂具有抑制或延缓阿尔茨海默病进展的作用，即使长期使用也能对阿尔茨海默病产生持久的治疗效果。本发明提供了一种阿尔茨海默病的治疗剂或预防剂，所述治疗剂作为有效成分包括如下式所示的环己烷衍生物，或其药学上可接受的盐或其原药。
• THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR FIBROMYALGIA
  申请人：Yoshida Chihiro

  公开号：US20130190503A1

  公开（公告）日：2013-07-25

  A therapeutic agent or prophylactic agent has an analgesic effect on both nociceptive pain and neuropathic pain and is effective in treatment of fibromyalgia. The agent includes as an effective ingredient a cyclohexane derivative or a pharmaceutically acceptable salt thereof or a prodrug thereof.
• US8247569B2
  申请人：——

  公开号：US8247569B2

  公开（公告）日：2012-08-21
• US8957094B2
  申请人：——

  公开号：US8957094B2

  公开（公告）日：2015-02-17