3-mesityl-4-methylthiazolie-2(3H)-thione | 1118487-74-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-mesityl-4-methylthiazolie-2(3H)-thione
• 英文别名: 3-mesityl-4-methylthiazole-2(3H)-thione
• CAS: 1118487-74-3
• 化学式: C₁₃H₁₅NS₂
• 分子量: 249.401
• InChiKey: DLRMVBYDCKLEJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  4.93
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3-mesityl-4-methylthiazolie-2(3H)-thione 、 bis(trifluoromethane)sulfonimide lithium 在 双氧水 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 1.5h， 以97%的产率得到3-mesityl-4-methylthiazol-3-ium bis((trifluoromethyl)sulfonyl)imide
  参考文献：
  名称：

  N-Heterocyclic Carbene-Mediated Oxidative Electrosynthesis of Esters in a Microflow Cell

  摘要：

  An efficient N-heterocyclic carbene (NHC)-mediated oxidative esterification of aldehydes has been achieved in an undivided microfluidic electrolysis C-ell at ambient temperature. Productivities of up to 4.3 g h(-1) in a single pass are demonstrated, with excellent yields, and conversions for 19 examples presented: Notably, the oxidative acylation, reactions were,shown to proceed with a 1:1 stoichiometry of aldehyde and alcohol (for primary alcohols), with remarkably short residence tithes in the electrolysis cell (<13 s), and without added electrolyte.

  DOI：

  10.1021/acs.orglett.5b01459
• 作为产物：
  描述：

  二硫化碳 、 一氯丙酮 、 2,4,6-三甲基苯胺 在 sodium hydroxide 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 2.0h， 以66%的产率得到3-mesityl-4-methylthiazolie-2(3H)-thione
  参考文献：
  名称：

  N-Heterocyclic Carbene-Mediated Oxidative Electrosynthesis of Esters in a Microflow Cell

  摘要：

  An efficient N-heterocyclic carbene (NHC)-mediated oxidative esterification of aldehydes has been achieved in an undivided microfluidic electrolysis C-ell at ambient temperature. Productivities of up to 4.3 g h(-1) in a single pass are demonstrated, with excellent yields, and conversions for 19 examples presented: Notably, the oxidative acylation, reactions were,shown to proceed with a 1:1 stoichiometry of aldehyde and alcohol (for primary alcohols), with remarkably short residence tithes in the electrolysis cell (<13 s), and without added electrolyte.

  DOI：

  10.1021/acs.orglett.5b01459