Methyl 3-(N-acetylsulfamoyl)thiophene-2-carboxylate | 155449-86-8

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: Methyl 3-(N-acetylsulfamoyl)thiophene-2-carboxylate
• 英文别名: Methyl 3-(acetylsulfamoyl)thiophene-2-carboxylate
• CAS: 155449-86-8
• 化学式: C₈H₉NO₅S₂
• 分子量: 263.295
• InChiKey: RFJBUKNTZPFNCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  126
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Methyl 3-(N-acetylsulfamoyl)thiophene-2-carboxylate 在 Carbonate buffer 作用下， 以 乙腈 为溶剂， 生成 3-Acetylsulfamoyl-thiophene-2-carboxylic acid
  参考文献：
  名称：

  Transformation rates ofortho-substituted thiophene and benzene carboxylic esters: Application to thifensulfuron-methyl and metsulfuron-methyl herbicides

  摘要：

  AbstractThe rate constants for soil degradation and alkaline hydrolysis of two herbicides, metsulfuron‐methyl and thifensulfuron‐methyl, have been determined. In order to explain the difference in behaviour of the two compounds, the chemical and enzymatic hydrolysis of some ortho‐substituted methyl benzoates and methyl 3‐substituted thiophene‐2‐carboxylates were studied. The data are consistent with a difference in polar and steric effects of the substituents in benzene and thiophene derivatives.

  DOI：

  10.1002/ps.2780400407
• 作为产物：
  描述：

  3-氯磺酰基-2-噻吩甲酸甲酯 在 ammonium hydroxide 作用下， 以 丙酮 为溶剂， 反应 13.0h， 生成 Methyl 3-(N-acetylsulfamoyl)thiophene-2-carboxylate
  参考文献：
  名称：

  Transformation rates ofortho-substituted thiophene and benzene carboxylic esters: Application to thifensulfuron-methyl and metsulfuron-methyl herbicides

  摘要：

  AbstractThe rate constants for soil degradation and alkaline hydrolysis of two herbicides, metsulfuron‐methyl and thifensulfuron‐methyl, have been determined. In order to explain the difference in behaviour of the two compounds, the chemical and enzymatic hydrolysis of some ortho‐substituted methyl benzoates and methyl 3‐substituted thiophene‐2‐carboxylates were studied. The data are consistent with a difference in polar and steric effects of the substituents in benzene and thiophene derivatives.

  DOI：

  10.1002/ps.2780400407

文献信息

• Arylsulfonylacetamides as bifunctional reagents for alkene aminoarylation
  作者：Timothy M. Monos、Rory C. McAtee、Corey R. J. Stephenson

  DOI：10.1126/science.aat2117

  日期：2018.9.28

  process, single-electron alkene oxidation enables carbon-nitrogen bond formation to provide a key benzylic radical poised for a Smiles-Truce 1,5-aryl shift. This reaction is redox-neutral, exhibits broad functional group compatibility, and occurs at room temperature with loss of sulfur dioxide. As this process is driven by visible light, uses readily available starting materials, and demonstrates convergent

  来自单一来源的芳烃和酰胺药物合成通常需要形成相邻的碳-碳和碳-氮键。莫诺斯等人。提出了一种将碳和氮组分传递到单一试剂中的方法，特别是通过二氧化硫连接到酰胺的芳基环。光活化催化剂引发烯烃与氮反应，进而导致芳基环迁移和硫桥损失。高效的室温工艺适用于各种不同的芳烃，包括杂环。科学，本期第 3 页。1369 Photoredox 催化激活烯烃通过与单一试剂偶联形成相邻的 C-C 和 C-N 键。使用单一双功能试剂进行烯烃氨基芳基化是一种简洁的合成策略。我们报告了一种催化方案，用于在富电子烯烃中添加芳基磺酰乙酰胺，具有完全的抗马尔科夫尼科夫区域选择性和出色的非对映选择性，以提供 2,2-二芳基乙胺。在这个过程中，单电子烯烃氧化能够形成碳-氮键，从而为 Smiles-Truce 1,5-芳基位移提供关键的苄基自由基。该反应是氧化还原中性的，表现出广泛的官能团相容性，并且在室温下发生并损失二氧化硫。由于
• US9661852B1
  申请人：——

  公开号：US9661852B1

  公开（公告）日：2017-05-30