(S)-2-amino-6-guanidino-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)hexanamide | 1538609-10-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (S)-2-amino-6-guanidino-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)hexanamide
• 英文别名: (2S)-2-amino-6-(diaminomethylideneamino)-N-[4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]phenyl]sulfonylhexanamide
• CAS: 1538609-10-7
• 化学式: C₂₄H₂₈F₃N₇O₃S
• 分子量: 551.593
• InChiKey: PKWRLOAXUYQNOX-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  180
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• NO-RELEASING GUANIDINE-COXIB ANTI-CANCER AGENTS
  申请人：Euclises Pharmaceuticals, Inc

  公开号：US20140018403A1

  公开（公告）日：2014-01-16

  The present disclosure provides NO-releasing guanidine-coxib anti-cancer agents, having the structure of Formula (I): wherein R 1 , R 11 , Z and L are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, acne, or a disease mediated by arginine deficiency using a compound of Formula (I).

  本公开提供了一种具有NO释放的guanidine-coxib抗癌剂，其结构式为（I）：其中R1，R11，Z和L如详细描述中所定义；包含至少一种化合物（I）的药物组合物；以及使用化合物（I）治疗创伤、预防和治疗癌症、治疗光化性角化症、囊性纤维化、痤疮或由精氨酸缺乏介导的疾病的有用方法。
• US9044464B2
  申请人：——

  公开号：US9044464B2

  公开（公告）日：2015-06-02
• [EN] NO-RELEASING GUANIDINE-COXIB ANTI-CANCER AGENTS<br/>[FR] AGENTS ANTICANCÉREUX GUANIDINE-COXIB À LIBÉRATION DE NO
  申请人：EUCLISES PHARMACEUTICALS INC

  公开号：WO2014012000A2

  公开（公告）日：2014-01-16

  The present disclosure provides NO-releasing guanidine-coxib anti-cancer agents, having the structure of Formula (I): wherein R1, R11, Z and L are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, acne, or a disease mediated by arginine deficiency using a compound of Formula (I).