1-(4-Chlorphenyl)-5-methyl-1,2,4-triazol-3-carbaldehyd | 91587-69-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-Chlorphenyl)-5-methyl-1,2,4-triazol-3-carbaldehyd
• 英文别名: 1-(4-chloro-phenyl)-5-methyl-1H-[1,2,4]triazole-3-carbaldehyde；1-(4-Chlorophenyl)-5-methyl-1,2,4-triazole-3-carbaldehyde
• CAS: 91587-69-8
• 化学式: C₁₀H₈ClN₃O
• 分子量: 221.646
• InChiKey: LBRODLOHCIOECN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  47.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Cyclin Based Inhibitors of CDK2 and CDK4
  申请人：McInnes Campbell

  公开号：US20130289240A1

  公开（公告）日：2013-10-31

  Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.

  研究了肽抑制剂与环D和环A凹槽的结构和功能分析，并用于设计肽，为结构活性关系提供基础，改善结合并具有作为化学生物学探针、潜在诊断和治疗增殖性疾病（包括癌症和炎症）的潜力。
• CYCLIN BASED INHIBITORS OF CDK2 AND CDK4
  申请人：McInnes Campbell

  公开号：US20140316107A1

  公开（公告）日：2014-10-23

  Structural and functional analysis of peptide inhibitor binding to the cyclin D1 groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.
• US8566072B2
  申请人：——

  公开号：US8566072B2

  公开（公告）日：2013-10-22
• US9328139B2
  申请人：——

  公开号：US9328139B2

  公开（公告）日：2016-05-03
• US9376465B2
  申请人：——

  公开号：US9376465B2

  公开（公告）日：2016-06-28