(Z)-5-(4-methoxy-benzylidene)-2-(4-methyl-piperazin-1-yl)-thiazol-4-one | 1347744-92-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (Z)-5-(4-methoxy-benzylidene)-2-(4-methyl-piperazin-1-yl)-thiazol-4-one
• 英文别名: (Z)-5-(4-methoxybenzylidene)-2-(4-methylpiperazin-1-yl)thiazol-4(5H)-one；(5Z)-5-[(4-methoxyphenyl)methylidene]-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-one
• CAS: 1347744-92-6
• 化学式: C₁₆H₁₉N₃O₂S
• 分子量: 317.412
• InChiKey: RLENGPISDPPDMP-KAMYIIQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  70.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-甲基哌嗪 、 罗丹宁 、 4-甲氧基苯甲醛 在 silica-based substituted pyridine catalyst 7 作用下， 以 乙醇 、 水 为溶剂， 反应 1.73h， 以82%的产率得到(Z)-5-(4-methoxy-benzylidene)-2-(4-methyl-piperazin-1-yl)-thiazol-4-one
  参考文献：
  名称：

  Rapid and straightforward one-pot expeditious synthesis of 2-amino-5-alkylidene-thiazol-4-ones at room temperature

  摘要：

  A new methodology has been developed towards the room temperature synthesis of novel 2-amino-5-alkylidenethiazol-4-ones from aldehydes, amines and rhodanine in one-pot. A heterogeneous dipolar catalyst has been utilized for this reaction. The unique properties of this catalyst effectively synthesize such compounds at room temperature in contrast to all earlier reports. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.090

文献信息

• Rapid and straightforward one-pot expeditious synthesis of 2-amino-5-alkylidene-thiazol-4-ones at room temperature
  作者：Chhanda Mukhopadhyay、Suman Ray

  DOI：10.1016/j.tetlet.2011.09.090

  日期：2011.11

  A new methodology has been developed towards the room temperature synthesis of novel 2-amino-5-alkylidenethiazol-4-ones from aldehydes, amines and rhodanine in one-pot. A heterogeneous dipolar catalyst has been utilized for this reaction. The unique properties of this catalyst effectively synthesize such compounds at room temperature in contrast to all earlier reports. (C) 2011 Elsevier Ltd. All rights reserved.