1,8-Bis(cystineyl)-3,6-dioxa-octane Dihydrochloride | 1356019-49-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,8-Bis(cystineyl)-3,6-dioxa-octane Dihydrochloride
• 英文别名: (2R)-2-amino-3-[2-[2-[2-[(2R)-2-amino-2-carboxyethyl]sulfanylethoxy]ethoxy]ethylsulfanyl]propanoic acid
• CAS: 1356019-49-2
• 化学式: C₁₂H₂₄N₂O₆S₂
• 分子量: 356.464
• InChiKey: QLOKIVQVNAGFNY-UWVGGRQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  196
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  1,8-Bis(cystineyl)-3,6-dioxa-octane Dihydrochloride 在 氯化亚砜 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 36.0h， 生成 dimethyl (6R,19R)-4,21-dioxo-2,11,14,23-tetraoxa-8,17-dithia-5,20-diazatricyclo[22.5.3.027,31]dotriaconta-1(30),24(32),25,27(31),28-pentaene-6,19-dicarboxylate
  参考文献：
  名称：

  Novel chiral fluorescent macrocyclic receptors: synthesis and recognition for amino acid anions

  摘要：

  New chiral fluorescence macrocycles 1 and 2 containing naphthalene and amino acid units were synthesized. The binding properties for amino acid anions were examined by the fluorescence and H-1 NMR spectra. The results indicated good enantio selectivity of 1 toward the N-protected phenylalanine anions. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.037
• 作为产物：
  描述：

  L-半胱氨酸 、 1,2-二(2-氯乙氧基)乙烷 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 1,8-Bis(cystineyl)-3,6-dioxa-octane Dihydrochloride
  参考文献：
  名称：

  Novel chiral fluorescent macrocyclic receptors: synthesis and recognition for amino acid anions

  摘要：

  New chiral fluorescence macrocycles 1 and 2 containing naphthalene and amino acid units were synthesized. The binding properties for amino acid anions were examined by the fluorescence and H-1 NMR spectra. The results indicated good enantio selectivity of 1 toward the N-protected phenylalanine anions. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.037

文献信息

• Novel chiral fluorescent macrocyclic receptors: synthesis and recognition for amino acid anions
  作者：Haijuan Qin、Yongbing He、Guangyan Qing、Chenguang Hu、Xi Yang

  DOI：10.1016/j.tetasy.2006.07.037

  日期：2006.8

  New chiral fluorescence macrocycles 1 and 2 containing naphthalene and amino acid units were synthesized. The binding properties for amino acid anions were examined by the fluorescence and H-1 NMR spectra. The results indicated good enantio selectivity of 1 toward the N-protected phenylalanine anions. (c) 2006 Elsevier Ltd. All rights reserved.