2-hydroxy-3-[5-(3-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid | 1032614-75-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-hydroxy-3-[5-(3-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid
• 英文别名: 2-Hydroxy-3-[5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]benzoic acid
• CAS: 1032614-75-7
• 化学式: C₁₆H₉F₃N₂O₄
• 分子量: 350.254
• InChiKey: IRIKUFYBOKSMOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  96.4
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, composistions thereof and the use for nonsense suppression
  申请人：Almstead Neil G.

  公开号：US20080139632A1

  公开（公告）日：2008-06-12

  Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

  本发明公开了一种新型的羟基化1,2,4-噁二唑苯甲酸衍生物化合物，以及使用该羟基化1,2,4-噁二唑苯甲酸衍生物的方法和包含该化合物的药物组合物。该方法包括治疗或预防通过调节过早翻译终止或无意义介导的mRNA降解而改善的疾病，或改善与之相关的一个或多个症状的方法。
• HYDROXYLATED 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS, COMPOSITIONS THEREOF AND THEIR USE IN BIOASSAYS
  申请人：Almstead Neil G.

  公开号：US20120087896A1

  公开（公告）日：2012-04-12

  Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
• US8101641B2
  申请人：——

  公开号：US8101641B2

  公开（公告）日：2012-01-24
• US8691511B2
  申请人：——

  公开号：US8691511B2

  公开（公告）日：2014-04-08