Tyr-dimethylamid | 46440-40-8

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: Tyr-dimethylamid
• 英文别名: (2S)-2-amino-3-(4-hydroxyphenyl)-N,N-dimethylpropanamide
• CAS: 46440-40-8
• 化学式: C₁₁H₁₆N₂O₂
• 分子量: 208.26
• InChiKey: YHVJCWPOEZQLQY-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tyr-dimethylamid 在 钯 氢气 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Asp-Tyr-dimethylamid
  参考文献：
  名称：

  一些二肽的结构-味道关系。

  摘要：

  DOI：

  10.1021/ja01038a046
• 作为产物：
  描述：

  [(S)-1-Dimethylcarbamoyl-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid benzyl ester 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 Tyr-dimethylamid
  参考文献：
  名称：

  Structure–activity relationships of the peptide deformylase inhibitor BB-3497: modification of the P2′ and P3′ side chains

  摘要：

  Structural modifications to the peptide deformylase inhibitor BB-3497 are described. In this paper, we describe the initial SAR around this lead for modifications to both the P2' and P3' side chains. Enzyme inhibition and antibacterial activity data revealed that a variety of substituents are tolerated at the P2' and P3' positions of the inhibitor backbone. The data from this study highlights the potential for modification at the P2' and P3' positions to optimise the physicochemical properties. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00533-x

文献信息

• ORALLY AVAILABLE VIRIDIOFUNGIN DERIVATIVE POSSESSING ANTI-HCV ACTIVITY
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20150210666A1

  公开（公告）日：2015-07-30

  An object of the present invention is to provide a compound that is useful as an orally available anti-HCV agent. The present invention relates to a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. This compound has an anti-HCV activity and is useful as a medicine.

  本发明的目的是提供一种可口服的抗丙型肝炎病毒药物化合物。本发明涉及一种由式（1）所表示的化合物或其药学上可接受的盐。该化合物具有抗丙型肝炎病毒的活性，是一种有用的药物。
• Dimethyl tyrosyl amide sulfides, sulfoxides and sulfones
  申请人：G.D. Searle & Co.

  公开号：EP0361482A1

  公开（公告）日：1990-04-04

  Dimethyl tyrosyl amide sulfides, sulfoxides and sulfones that are useful as opioid analgesics.

  可用作阿片类镇痛剂的二甲基酪氨酰硫化物、硫醚和砜。
• Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor
  作者：Yongqi Deng、Gerald W. Shipps、Lianyun Zhao、M. Arshad Siddiqui、Janeta Popovici-Muller、Patrick J. Curran、Jose S. Duca、Alan W. Hruza、Thierry O. Fischmann、Vincent S. Madison、Rumin Zhang、Charles W. McNemar、Todd W. Mayhood、Rosalinda Syto、Allen Annis、Paul Kirschmeier、Emma M. Lees、David A. Parry、William T. Windsor

  DOI：10.1016/j.bmcl.2013.11.041

  日期：2014.1

  A new class of quinoline-based kinase inhibitors has been discovered that both disrupt cyclin dependent 2 (CDK2) interaction with its cyclin A subunit and act as ATP competitive inhibitors. The key strategy for discovering this class of protein-protein disrupter compounds was to screen the monomer CDK2 in an affinity-selection/mass spectrometry-based technique and to perform secondary assays that identified compounds that bound only to the inactive CDK2 monomer and not the active CDK2/cyclin A heterodimer. Through a series of chemical modifications the affinity (Kd) of the original hit improved from 1 to 0.005μM.
• US9266853B2
  申请人：——

  公开号：US9266853B2

  公开（公告）日：2016-02-23