1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-6-vinyl-1,4-dihydroquinoline-3-carboxamide | 1351945-36-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-6-vinyl-1,4-dihydroquinoline-3-carboxamide
• CAS: 1351945-36-2
• 化学式: C₂₆H₁₉F₃N₂O₂
• 分子量: 448.444
• InChiKey: REOKKUZWKCYAKD-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-6-vinyl-1,4-dihydroquinoline-3-carboxamide 在 sodium periodate 、 四氧化锇 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.0h， 生成 6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide
  参考文献：
  名称：

  Optimization of a Potent, Orally Active S1P₁ Agonist Containing a Quinolinone Core

  摘要：

  The optimization of a series of SIP, agonists with limited activity against S1P(3) is reported. A polar headgroup was used to improve the physicochemical and pharmacokinetic parameters of lead quinolinone 6. When dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22 achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22 was dosed orally at 2 and 100 mg/kg.

  DOI：

  10.1021/ml200252b
• 作为产物：
  描述：

  2-(trifluoromethyl)biphenyl-4-amine 在 二(三叔丁基膦)钯 、 三叔丁基膦 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 三乙胺 、 cesium fluoride 作用下， 以 1,4-二氧六环 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 52.0h， 生成 1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-6-vinyl-1,4-dihydroquinoline-3-carboxamide
  参考文献：
  名称：

  Optimization of a Potent, Orally Active S1P₁ Agonist Containing a Quinolinone Core

  摘要：

  The optimization of a series of SIP, agonists with limited activity against S1P(3) is reported. A polar headgroup was used to improve the physicochemical and pharmacokinetic parameters of lead quinolinone 6. When dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22 achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22 was dosed orally at 2 and 100 mg/kg.

  DOI：

  10.1021/ml200252b