1-((2E)-3-(5-(5-methyl-2-(4-dimethylaminophenyl)oxazol-4-ylmethyl)furan-2-yl)-2-propenylthio)cyclobutanecarboxylic acid.ethyl ester | 264874-20-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-((2E)-3-(5-(5-methyl-2-(4-dimethylaminophenyl)oxazol-4-ylmethyl)furan-2-yl)-2-propenylthio)cyclobutanecarboxylic acid.ethyl ester
• 英文别名: ethyl 1-[(E)-3-[5-[[2-[4-(dimethylamino)phenyl]-5-methyl-1,3-oxazol-4-yl]methyl]furan-2-yl]prop-2-enyl]sulfanylcyclobutane-1-carboxylate
• CAS: 264874-20-6
• 化学式: C₂₇H₃₂N₂O₄S
• 分子量: 480.628
• InChiKey: ZRVXULQQQIFPNB-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  94
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US20030225145A1

  公开（公告）日：2003-12-04

  A peroxisome proliferator activated receptor regulator containing a compound of formula (I) 1 (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.

  一种过氧化物酶体增殖激活受体调节剂，其包含式（I）1的化合物（其中所有符号在规范中定义），或其盐作为活性成分。由于具有调节PPAR的作用，式（I）的化合物可用作降糖剂、降脂剂、预防和/或治疗代谢紊乱相关疾病（糖尿病、肥胖症、综合征X、高胆固醇血症、高脂蛋白血症等）、高脂血症、动脉粥样硬化、高血压、循环系统疾病、暴饮暴食、冠心病等、一种HDL胆固醇升高剂、一种LDL胆固醇和/或VLDL胆固醇降低剂，以及一种缓解糖尿病或综合征X风险因素的药物。
• CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1122255A1

  公开（公告）日：2001-08-08

  A peroxisome proliferator activated receptor regulator containing a compound of formula (I) (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.

  一种过氧化物酶体增殖物激活受体调节剂，含有式（I）化合物 (其中所有符号如说明书中所定义）或其盐作为活性成分。 由于具有调节 PPAR 的作用，式（I）化合物可用作降血糖剂、降血脂剂、预防和/或治疗代谢紊乱相关疾病（糖尿病、肥胖症、X 综合征、高胆固醇血症、高脂蛋白血症等）、高血脂症、动脉粥样硬化、高血压、循环系统疾病、暴饮暴食、冠心病等、提高高密度脂蛋白胆固醇的药物、降低低密度脂蛋白胆固醇和/或低密度脂蛋白胆固醇的药物以及缓解糖尿病或 X 综合征危险因素的药物。
• US6589969B1
  申请人：——

  公开号：US6589969B1

  公开（公告）日：2003-07-08
• US6821994B2
  申请人：——

  公开号：US6821994B2

  公开（公告）日：2004-11-23