ethyl 5-amino-1-(2,2,2-trifluoroethyl)-1H-imidazole-4-carboxylate | 915030-04-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 5-amino-1-(2,2,2-trifluoroethyl)-1H-imidazole-4-carboxylate
• 英文别名: ethyl 5-amino-1-(2,2,2-trifluoroethyl)imidazole-4-carboxylate
• CAS: 915030-04-5
• 化学式: C₈H₁₀F₃N₃O₂
• 分子量: 237.182
• InChiKey: MTGXAJLRGLOVLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES
  申请人：Blum Charles A.

  公开号：US20100008866A1

  公开（公告）日：2010-01-14

  Cis-cyclohexyl substituted pyrimidinone derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  本文提供了Cis-环己基取代嘧啶酮衍生物，其化学式为：其中变量如本文所述。这些化合物是配体，可用于体内或体外调节特定受体的活性，并且在治疗与人类、家养伴侣动物和家畜动物的病理受体激活相关的情况方面特别有用。本文还提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的配体的使用方法。
• Haloalkyl-substituted pyrimidinone derivatives
  申请人：Blum A. Charles

  公开号：US20080090845A1

  公开（公告）日：2008-04-17

  Haloalkyl-substituted pyrimidinone derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了Haloalkyl-取代的嘧啶酮衍生物，其化学式为：其中变量如本文所述。这些化合物是配体，可用于调节体内或体外特定受体活性，并且在治疗与人类、家养伴侣动物和家畜动物的病理性受体激活相关的疾病方面特别有用。还提供了用于治疗此类疾病的制药组合物和方法，以及使用此类配体进行受体定位研究的方法。
• 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1)
  申请人：Brown Rebecca Elizabeth

  公开号：US20090298856A1

  公开（公告）日：2009-12-03

  The use of a compound of formula (I): for the manufacture of a medicament for the treatment of conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1, also known as TRPV1).

  使用化合物(I)的制剂，用于制造治疗通过调节vanilloid-1受体（VR1，又称TRPV1）功能改善的疾病的药物。
• [EN] SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES<br/>[FR] DÉRIVÉS D'ARYLPYRIMIDONE SUBSTITUÉS
  申请人：NEUROGEN CORP

  公开号：WO2009121036A2

  公开（公告）日：2009-10-01

  Substituted aryl pyrimidinone derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.