6-(n-propylamino)hexanoic acid | 244055-04-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(n-propylamino)hexanoic acid
• 英文别名: 6-N-propylamino caproic acid；6-(Propylamino)hexanoic acid
• CAS: 244055-04-7
• 化学式: C₉H₁₉NO₂
• 分子量: 173.255
• InChiKey: QIICHZWOUFYGIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(n-propylamino)hexanoic acid 以 四氢呋喃 、 水 为溶剂， 反应 8.0h， 生成 C₃₄H₄₃N₃O₆
  参考文献：
  名称：

  Preparation and Evaluation of Proline-Based Chiral Columns

  摘要：

  制备了由容易获得的脯氨酸肽制成的手性固定相，并对其进行了一般手性分离的评估。通过适当的结构元素，这些柱表现出广泛的手性选择性。在测试的 53 种分析物中，四脯氨酸色谱柱分离了 31 种。这些分析物实现的分离效果与 Whelk O2 色谱柱实现的分离效果相当，但仍低于 Daicel AD-H 和 OD-H 色谱柱实现的分离效果。脯氨酸单元的数量被证明对于手性识别很重要，因为用单个脯氨酸单元制成的对照柱基本上是无效的。

  DOI：

  10.1021/ac050050s
• 作为产物：
  描述：

  6-氨基己酸己基酯 在 sodium hydroxide 、 sodium cyanoborohydride 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 反应 49.0h， 生成 6-(n-propylamino)hexanoic acid
  参考文献：
  名称：

  A comparison of flexible and constrained haptens in eliciting antibody catalysts for paraoxon hydrolysis

  摘要：

  A new amine-oxide hapten was employed as an antigen, producing seven monoclonal antibodies (mAbs) from a panel of 20 that catalyzed paraoxon hydrolysis. The current hapten design differs from that previously described in that the molecule is inherently more flexible than its constrained predecessor. One of the seven antibody catalysts, mAb 1H9, showed the highest activity and was selected for detailed study. At pH = 8.77, the catalytic hydrolysis of paraoxon by mAb 1H9 followed Michaelis-Menten kinetics affording a k(cat) = 3.73 x 10(-4) min(-1) and a K-m,= 1.12 mM with a rate acceleration k(cat)/k(uncat) = 56. The hapten was found to be a competitive inhibitor of antibody-catalyzed paraoxon hydrolysis with a K-i,= 0.54 mM. A comparison of both the number and proficiency of antibody catalysts obtained when utilizing a flexible versus constrained hapten indicates that, for paraoxon hydrolysis, constrained haptens elicit superior catalysts, suggesting that further development should begin with the use of constrained haptens in producing more proficient antibody catalysts for paraoxon hydrolysis. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00026-7

文献信息

• Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
  申请人：3-Dimensional Pharmaceuticals, Inc.

  公开号：US20030105111A1

  公开（公告）日：2003-06-05

  The present invention is directed to a compound of Formula I: 1 wherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.

  本发明涉及一种具有以下结构的化合物：其中A、R1和R2在此处被定义。本发明还涉及包含Formula I化合物的组合物、使用Formula I化合物的方法以及制备Formula I化合物的方法。
• 氟乐灵半抗原及其制备方法和应用
  申请人：广东第二师范学院

  公开号：CN106928079B

  公开（公告）日：2019-02-22

  本发明公开了氟乐灵半抗原及其制备方法和应用，其具有如下结构式：其中，R为‑(CH2)n‑，n＝1‑4或‑CH＝CH‑或本发明的六种半抗原均是在氨基位点上衍生连接手臂，具有活性羧基，与载体蛋白偶联后能使机体产生效价高，能识别氟乐灵农药共有结构的特异抗体。本发明的半抗原化合物，不仅合成方法简便、纯度较高，而且能应用于合成适于动物免疫的抗原体系，弥补了国内氟乐灵免疫学检测方法技术领域的空白，为氟乐灵免疫检测方法的进一步发展奠定了基础。
• SUBSTITUTED DIPHENYLOXAZOLES, THE SYNTHESIS THEREOF, AND THE USE THEREOF AS FLUORESCENCE PROBES
  申请人：3-DIMENSIONAL PHARMACEUTICALS, INC.

  公开号：EP1442027A1

  公开（公告）日：2004-08-04
• PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20200087399A1

  公开（公告）日：2020-03-19

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.
• METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20210317407A1

  公开（公告）日：2021-10-14

  Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.