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2-[2-(4-benzyloxyphenyl)-5-methyloxazol-4-yl]ethyl methanesulfonate | 477541-36-9

中文名称
——
中文别名
——
英文名称
2-[2-(4-benzyloxyphenyl)-5-methyloxazol-4-yl]ethyl methanesulfonate
英文别名
2-[5-Methyl-2-(4-phenylmethoxyphenyl)-1,3-oxazol-4-yl]ethyl methanesulfonate
2-[2-(4-benzyloxyphenyl)-5-methyloxazol-4-yl]ethyl methanesulfonate化学式
CAS
477541-36-9
化学式
C20H21NO5S
mdl
——
分子量
387.456
InChiKey
GPICAEHKJBSTPA-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.6
  • 重原子数:
    27
  • 可旋转键数:
    8
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.25
  • 拓扑面积:
    87
  • 氢给体数:
    0
  • 氢受体数:
    6

文献信息

  • Novel heterocyclic derivatives and medicinal use thereof
    申请人:——
    公开号:US20040180924A1
    公开(公告)日:2004-09-16
    The novel heterocyclic derivative of the present invention is a novel heterocyclic derivative having the formula (I′) 1 wherein R 1 is a hydrogen atom or C 1-6 alkyl, R 2 is —CO—C(R 4 )═C(R 4 )—R 5 wherein R 4 is a hydrogen atom or C 1-4 alkyl, and R 5 is C 4-8 alkyl, C 2-8 alkenyl, aryl or aromatic heterocycle, —CO—C≡C—R 6 wherein R 6 is C 1-8 alkyl and the like, R 3 is a hydrogen atom or C 1-4 alkyl, X is an oxygen atom or a sulfur atom, R 20 is optionally substituted phenyl, and n is an integer of 1 to 4, or a pharmaceutically acceptable salt thereof. The compound (I′) of the present invention is useful as a hypoglycemic agent, a hypolipidemic agent, an insulin resistance improver, a therapeutic agent of diabetes, a therapeutic agent of diabetic complications, a glucose tolerance improver, an anti-arteriosclerosis agent, an anti-obesity agent, an antiinflammatory agent, an agent for the prophylaxis or treatment of PPAR-mediated diseases and an agent for the prophylaxis or treatment of syndrome X.
    本发明的新型杂环衍生物是一种具有公式(I')的新型杂环衍生物,其中R1是氢原子或C1-6烷基,R2是—CO—C(R4)═C(R4)—R5,其中R4是氢原子或C1-4烷基,R5是C4-8烷基、C2-8烯基、芳香族或芳香族杂环,—CO—C≡C—R6,其中R6是C1-8烷基等,R3是氢原子或C1-4烷基,X是氧原子或原子,R20是可选取代的苯基,n是1到4的整数,或其药学上可接受的盐。本发明的化合物(I')可用作降血糖剂、降血脂剂、胰岛素抵抗改善剂、糖尿病治疗剂、糖尿病并发症治疗剂、葡萄糖耐量改善剂、抗动脉硬化剂、抗肥胖剂、抗炎剂、预防或治疗PPAR介导的疾病的药剂和预防或治疗X综合征的药剂。
  • NOVEL HETEROCYCLIC DERIVATIVES AND MEDICINAL USE THEREOF
    申请人:Kyoto Pharmaceutical Industries, Ltd.
    公开号:EP1398313A1
    公开(公告)日:2004-03-17
    The novel heterocyclic derivative of the present invention is a novel heterocyclic derivative having the formula (I') wherein R1 is a hydrogen atom or C1-6 alkyl, R2 is -CO-C(R4)=C(R4)-R5 wherein R4 is a hydrogen atom or C1-4 alkyl, and R5 is C4-8 alkyl, C2-8 alkenyl, aryl or aromatic heterocycle, -CO-C≡C-R6 wherein R6 is C1-8 alkyl and the like, R3 is a hydrogen atom or C1-4 alkyl, X is an oxygen atom or a sulfur atom, R20 is optionally substituted phenyl, and n is an integer of 1 to 4, or a pharmaceutically acceptable salt thereof. The compound (I') of the present invention is useful as a hypoglycemic agent, a hypolipidemic agent, an insulin resistance improver, a therapeutic agent of diabetes, a therapeutic agent of diabetic complications, a glucose tolerance improver, an anti-arteriosclerosis agent, an anti-obesity agent, an antiinflammatory agent, an agent for the prophylaxis or treatment of PPAR-mediated diseases and an agent for the prophylaxis or treatment of syndrome X.
    本发明的新型杂环衍生物是具有式(I')的新型杂环衍生物 其中 R1 是氢原子或 C1-6 烷基,R2 是 -CO-C(R4)=C(R4)-R5 其中 R4 是氢原子或 C1-4 烷基,R5 是 C4-8 烷基、C2-8 烯基、芳基或芳香杂环,-CO-C≡C-R6 其中 R6 是 C1-8 烷基等,R3 是氢原子或 C1-4 烷基,X 是氧原子或原子,R20 是任选取代的苯基,n 是 1 至 4 的整数,或其药学上可接受的盐。本发明的化合物(I')可用作降血糖剂、降血脂剂、胰岛素抵抗改善剂、糖尿病治疗剂、糖尿病并发症治疗剂、葡萄糖耐量改善剂、抗动脉硬化剂、抗肥胖剂、抗炎剂、预防或治疗 PPAR 介导的疾病的药物以及预防或治疗 X 综合征的药物。
  • US6872732B2
    申请人:——
    公开号:US6872732B2
    公开(公告)日:2005-03-29
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