N-<2-(2-Methyl-pyridyl-5)-ethyl>-1,2,3,4-tetrahydro-carbazol | 96972-68-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-<2-(2-Methyl-pyridyl-5)-ethyl>-1,2,3,4-tetrahydro-carbazol
• 英文别名: N-<2-(6-Methyl-pyridyl-3)-ethyl>-1,2,3,4-tetrahydro-carbazol；9-[2-(6-methyl-pyridin-3-yl)-ethyl]-1,2,3,4-tetrahydro-carbazole；9-[2-(6-Methylpyridin-3-yl)ethyl]-1,2,3,4-tetrahydrocarbazole
• CAS: 96972-68-8
• 化学式: C₂₀H₂₂N₂
• 分子量: 290.408
• InChiKey: OFUJZTCCMDVHRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-y-CARBOLINE AND ANALOGUES AND INTERMEDIATES
  申请人：Williamson Craig

  公开号：US20110245504A1

  公开（公告）日：2011-10-06

  The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds.

  本发明涉及制备某些9-(芳基烷基)-1,2,3,4-四氢-γ-咔啉化合物及其类似物的方法，特别是制备地美莫辛的方法。本发明还涉及制备某些中间化合物的方法，这些中间化合物在合成9-(芳基烷基)-1,2,3,4-四氢-γ-咔啉化合物时有用。
• US8703952B2
  申请人：——

  公开号：US8703952B2

  公开（公告）日：2014-04-22
• [EN] SYNTHESIS OF 9-(ARYLALKYL)-1,2,3,4-TETRAHYDRO-?-CARBOLINE AND ANALOGUES AND INTERMEDIATES<br/>[FR] SYNTHÈSES DE 9-(ARYLALKYL)-1,2,3,4-TÉTRAHYDRO-GAMMA-CARBOLINE, DE SES ANALOGUES, ET DE SES INTERMÉDIAIRES
  申请人：WISTA LAB LTD

  公开号：WO2010067085A2

  公开（公告）日：2010-06-17

  The present invention pertains generally to methods of preparing certain 9-(arylalkyl)- 1,2,3,4-tetrahydro-Υ-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds.