2-(3,4-Difluoro-phenylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one | 352360-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 2-(3,4-Difluoro-phenylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one
• 英文别名: 2-(3,4-Difluoroanilino)-8-ethylpyrido[2,3-d]pyrimidin-7-one
• CAS: 352360-12-4
• 化学式: C₁₅H₁₂F₂N₄O
• 分子量: 302.283
• InChiKey: KRGIKPGUBONQQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  58.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Pyridopyrimidinone derivatives for treatment of neurodegenerative disease
  申请人：——

  公开号：US20040224958A1

  公开（公告）日：2004-11-11

  This invention provides pyridopyrimidines and 4-aminopyrimidines that are useful for treating cell proliferatives disorders, such as cancer and restenosis. We have now discovered a group of 7,8-dihydro-2 (amino and thio)pyrido[2,3-d]pyrimidines and 2,4-diaminopyrimidines that are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention provides compounds of Formula (I) and Formula (II) where W is NH, S, SO, or SO 2 , R 1 includes phenyl and substituted phenyl, R 2 includes alkyl and cycloalkyl, R 3 includes alkyl and hydrogen, R 8 and R 9 include hydrogen and alkyl, and Z is carboxy. This invention also provide pharmaceutical formulations comprising a compound of Formula (I or II) together with a pharmaceutically acceptable carrier, diluent, or excipient therefor. 1

  这项发明提供了对治疗细胞增殖性疾病（如癌症和再狭窄）有用的吡啶吡嘧啶和4-氨基吡嘧啶。我们现在发现了一组7,8-二氢-2（氨基和硫）吡啶嘧啶和2,4-二氨基吡嘧啶，它们是细胞周期依赖性激酶（cdk）和生长因子介导的激酶的有效抑制剂。这些化合物易于合成，并且可以通过多种途径（包括口服）给药，具有足够的生物利用度。该发明提供了式（I）和式（II）的化合物，其中W为NH、S、SO或SO2，R1包括苯基和取代苯基，R2包括烷基和环烷基，R3包括烷基和氢，R8和R9包括氢和烷基，Z为羧基。该发明还提供了含有式（I或II）化合物的制剂，与其一起使用的药用可接受载体、稀释剂或赋形剂。
• PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1255755A1

  公开（公告）日：2002-11-13
• [EN] PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE<br/>[FR] DERIVES DE PYRIDOPYRIMIDINONE DESTINES AU TRAITEMENT DE MALADIES MALADIE NEURODEGENERATIVE
  申请人：WARNER LAMBERT CO

  公开号：WO2001055148A1

  公开（公告）日：2001-08-02

  This invention provides a method for treating neurodegenerative diseases in mammals comprising administering an effective amount of a cyclin-dependent kinase inhibitor. A preferred method uses cdk inhibitors of Formula (I) and Formula (II) where W is NH, S, SO, or SO2, R1 includes phenyl and substituted phenyl, R2 includes alkyl and cycloalkyl, R3 includes alkyl and hydrogen, R?8 and R9¿ include hydrogen and alkyl, and Z is carboxy.