N-[N-[(phenylmethoxy)carbonyl]-L-leucyl]-L-valinol | 944281-95-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[N-[(phenylmethoxy)carbonyl]-L-leucyl]-L-valinol
• 英文别名: benzyl N-[(2S)-1-[[(2S)-1-hydroxy-3-methylbutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
• CAS: 944281-95-2
• 化学式: C₁₉H₃₀N₂O₄
• 分子量: 350.458
• InChiKey: UQLPACZKXCDMDE-DLBZAZTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[N-[(phenylmethoxy)carbonyl]-L-leucyl]-L-valinol 在 palladium 10% on activated carbon 氢气 、 sodium carbonate 作用下， 以 甲醇 、 水 、 乙酸乙酯 为溶剂， 生成 N-[N-(2-furanylcarbonyl)-L-leucyl]-L-valinol
  参考文献：
  名称：

  EP1972615

  摘要：

  公开号：

文献信息

• Cycloalkylcarbonylamino Acid Ester Derivative and Process for Producing The Same
  申请人：Kobayashi Nobuo

  公开号：US20090137799A1

  公开（公告）日：2009-05-28

  Cycloalkylcarbonylamino acid ester derivatives, which are raw material intermediates for a novel cycloalkane carboxamide derivative having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkylcarbonylamino acid ester derivative represented by formula (I), or a pharmaceutically acceptable salt thereof: (wherein, R 1 and R 2 represent alkyl groups, alkenyl groups, alkynyl groups, aromatic hydrocarbon groups, heterocyclic groups, etc., R 8 represents an alkyl group having 1 to 6 carbon atoms, and ring A represents a cyclic alkylidene group having 5, 6 or 7 carbon atoms).

  环烷基羰基氨基酸酯衍生物是一种新型环烷烃羧酰胺衍生物的原料中间体，具有选择性抑制卡特普辛K的作用，提供其生产工艺。 表示为式（I）的环烷基羰基氨基酸酯衍生物，或其药学上可接受的盐： （其中，R1和R2代表烷基、烯基、炔基、芳香烃基、杂环基等，R8代表具有1至6个碳原子的烷基，环A代表具有5、6或7个碳原子的环烷基亚基）。
• Cycloalkylcarbonylamino Acid Derivative and Process For Producing The Same
  申请人：Kobayashi Nobuo

  公开号：US20090111983A1

  公开（公告）日：2009-04-30

  Cycloalkylcarbonylamino acid derivatives, which are raw material intermediates of a novel cycloalkane carboxamide derivative that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkylcarbonylamino acid derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof: (wherein, R 1 and R 2 represent alkyl groups, alkenyl groups, alkynyl groups, aromatic hydrocarbon groups, heterocyclic groups or the like, and ring A represents a cyclic alkylidene group having 5, 6 or 7 carbon atoms).

  环烷基羰基氨基酸衍生物是一种新型环烷基羧酰胺衍生物的原料中间体，该衍生物选择性抑制卡特普辛K，并提供其生产工艺。 以下是由下述通用式（I）表示的环烷基羰基氨基酸衍生物，或其药用可接受盐： （其中，R1和R2代表烷基、烯基、炔基、芳香烃基、杂环基或类似基团，环A代表具有5、6或7个碳原子的环烷基亚基）。
• Cycloalkylcarbonylamino acid derivative and process for producing the same
  申请人：Kobayashi Nobuo

  公开号：US08481725B2

  公开（公告）日：2013-07-09

  Cycloalkylcarbonylamino acid derivatives, which are raw material intermediates of a novel cycloalkane carboxamide derivative that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkylcarbonylamino acid derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof: (wherein, R1 and R2 represent alkyl groups, alkenyl groups, alkynyl groups, aromatic hydrocarbon groups, heterocyclic groups or the like, and ring A represents a cyclic alkylidene group having 5, 6 or 7 carbon atoms).

  本发明提供了环烷基羰基氨基酸衍生物，它们是一种新型环烷基羧酰胺衍生物的原料中间体，该衍生物能够选择性地抑制卡他普星K，以及其生产工艺。所述环烷基羰基氨基酸衍生物由以下通式（I）表示，或其药学上可接受的盐：（其中，R1和R2表示烷基、烯基、炔基、芳香族烃基、杂环基或类似物，环A表示具有5、6或7个碳原子的环烷基亚基）。
• Cycloalkane carboxamide derivatives and production process of same
  申请人：Kobayashi Nobuo

  公开号：US08957205B2

  公开（公告）日：2015-02-17

  Novel cycloalkane carboxamide derivatives having an action that selectively inhibits cathepsin K, and a production process thereof, are provided, wherein the cycloalkane carboxamide derivatives are represented by the following general formula (I), or a pharmaceutically acceptable salt thereof: (wherein R1 and R2 represent (substituted) alkyl groups, (substituted) alkenyl groups, (substituted) alkynyl groups, (substituted) aromatic hydrocarbon groups or (substituted) heterocyclic groups, ring A represents an alkylidene group having 5 to 7 carbon atoms, and ring B represents a formyl group or a hydroxymethyl group).

  本发明提供了一种选择性抑制猫hepsin K的作用的新型环烷基羧酰胺衍生物及其生产方法，其中环烷基羧酰胺衍生物由以下通式（I）表示，或其药学上可接受的盐：（其中R1和R2代表（取代）烷基，（取代）烯基，（取代）炔基，（取代）芳香族碳氢基或（取代）杂环基，环A代表具有5至7个碳原子的烷基亚甲基基团，环B代表甲酰基或羟甲基基团）。
• Oxazolone derivative compounds having a 3-oxa-1-azaspiro[4.5] core
  申请人：Koji Tsuneo

  公开号：US08785631B2

  公开（公告）日：2014-07-22

  Novel raw material compounds are provided that are useful for producing novel cycloalkane carboxamide derivatives having cathepsin K inhibitory action. An oxazolone derivative represented by formula (I): [wherein, R1 represents a substituted or unsubstituted alkyl group, substituted or unsubstituted alkenyl group, substituted or unsubstituted alkynyl group, substituted phenyl group, substituted or unsubstituted naphthyl group or substituted or unsubstituted heterocyclic group, and ring A represents a saturated cyclic alkylidene group having 6 to 7 carbon atoms].

  提供了新型原料化合物，可用于生产具有猫hepsin K 抑制作用的新型环烷基羧酰胺衍生物。一种由式（I）表示的噁唑烷衍生物：[其中，R1表示取代或未取代的烷基，取代或未取代的烯基，取代或未取代的炔基，取代的苯基，取代或未取代的萘基或取代或未取代的杂环基，环A表示具有6至7个碳原子的饱和环烷基亚基]。