5-tert-pentyl-1,3-dihydro-benzimidazol-2-one | 100253-33-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5-tert-pentyl-1,3-dihydro-benzimidazol-2-one
• 英文别名: 5-tert-Pentyl-1,3-dihydro-benzimidazol-2-on；5-(2-Methylbutan-2-yl)-1,3-dihydrobenzimidazol-2-one
• CAS: 100253-33-6
• 化学式: C₁₂H₁₆N₂O
• 分子量: 204.272
• InChiKey: NBXCRBQDOYQTFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(4-叔戊基苯基)乙酰胺 在 硝酸 、 乙酸酐 、 溶剂黄146 作用下， 生成 5-tert-pentyl-1,3-dihydro-benzimidazol-2-one
  参考文献：
  名称：

  Synthesis of Some Substituted Benzoxazolones

  摘要：

  DOI：

  10.1021/ja01540a038

文献信息

• Thiazole compounds and methods of use
  申请人：Zeng Qingping

  公开号：US20090270445A1

  公开（公告）日：2009-10-29

  The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provided herein.

  本发明涉及使用I式和II式的噻唑化合物及其组合物治疗由蛋白激酶B（PKB）介导的疾病，例如癌症和其他增生性疾病的方法，其中变量具有此处提供的定义。
• Compositions and Methods Relating to Novel Compounds and Targets Thereof
  申请人：Glick Gary D.

  公开号：US20080293700A1

  公开（公告）日：2008-11-27

  The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.
• UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS
  申请人：Glick Gary D.

  公开号：US20120077805A1

  公开（公告）日：2012-03-29

  The present invention relates to systems and methods for generating new forms of benzodiazepine and benzodiazepine related compounds as well as new compounds and formulations generated by such methods. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline benzodiazepine and benzodiazepine related polymorphs and new unsolvated, solvated, and other forms of the compounds that find use as improved drugs and drug formations.
• US8084479B2
  申请人：——

  公开号：US8084479B2

  公开（公告）日：2011-12-27