2-propylpiperidine-1-carbonitrile | 98880-71-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: 2-propylpiperidine-1-carbonitrile
• 英文别名: 2-propyl-piperidine-1-carbonitrile；2-Propyl-piperidin-1-carbonitril
• CAS: 98880-71-8
• 化学式: C₉H₁₆N₂
• 分子量: 152.239
• InChiKey: QQVLMMFXELLNEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲醇 、 2-propylpiperidine-1-carbonitrile 在 N,N,N,N-tetraethylammonium tetrafluoroborate 作用下， 生成 2-Methoxy-6-propylpiperidine-1-carbonitrile 、 2-methoxy-2-propylpiperidine-1-carbonitrile
  参考文献：
  名称：

  High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines

  摘要：

  N-Protecting groups of alpha-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into alpha'-methoxylated compounds, while N-cyano derivatives changed into alpha-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the alpha-methoxylated compounds protected with cyano group afforded alpha,alpha-disubstituted cyclic amines. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.060
• 作为产物：
  描述：

  溴化氰 、 2-丙基哌啶 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以639 mg的产率得到2-propylpiperidine-1-carbonitrile
  参考文献：
  名称：

  High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines

  摘要：

  N-Protecting groups of alpha-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into alpha'-methoxylated compounds, while N-cyano derivatives changed into alpha-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the alpha-methoxylated compounds protected with cyano group afforded alpha,alpha-disubstituted cyclic amines. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.060

文献信息

• Lukes; Vesely, Collection of Czechoslovak Chemical Communications, 1957, vol. 22, p. 638
  作者：Lukes、Vesely

  DOI：——

  日期：——