2,2'-(2-(4-oxo-2-phenyl-4H-chromen-7-yloxy)ethylazanediyl)diacetic acid | 1250830-54-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2,2'-(2-(4-oxo-2-phenyl-4H-chromen-7-yloxy)ethylazanediyl)diacetic acid
• CAS: 1250830-54-6
• 化学式: C₂₁H₁₉NO₇
• 分子量: 397.384
• InChiKey: LZZXENAAMZPNAI-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 2,2'-(2-(4-oxo-2-phenyl-4H-chromen-7-yloxy)ethylazanediyl)diacetic acid
  参考文献：
  名称：

  Preparation of classical Re/99mTc(CO)3+ and novel 99mTc(CO)2(NO)2+ cores complexed with flavonol derivatives and their binding characteristics for Aβ(1–40) aggregates

  摘要：

  Classical Tc-99m(CO)(3)(+) and novel Tc-99m(CO)(2)(NO)(2+) cores complexed with flavonol derivatives were prepared. Autoradiography of postmortem AD transgenic mice (Tg C57, APP, PS1 12-month-old) brain section confirmed the binding property of [Tc-99m(CO)(3)(+)-3-OH-flavone](0) to A beta((1-40)) aggregates, while the novel Tc-99m(CO)(2)(NO)(2+) labeled compounds showed no binding sites in AD transgenic mice sections. Intravenous administration of [ 99mTc(CO)(3)(+)-3-OH-flavone](0) resulted in moderate brain uptake (0.48 +/- 0.05% ID/g) at 5 min post-injection and slow clearance from the brain issues in 2 h post-injection (120 min: 0.39 +/- 0.08% ID/g). Then an A beta((1-40))-receptor-targeted Re(CO)(3)(+)-3-OH-flavone, was prepared to identify the structure of the technetium complex. UV-vis absorption and fluorescence emission properties have been studied at room temperature in order to determine the natures of the lowest electronically excited states of Re(CO)(3)(+)-3-OH-flavone and the ligand. The fluorescent rhenium complex Re(CO)(3)(+)-3-OH-flavone showed high affinity for A beta((1-40)) aggregates in vitro by fluorescence spectra (dissociation constant (K-d) = 11.16 nM). In conclusion, the results suggested that Tc-99m(CO)(3)(+)-3-OH-flavone should be a suitable candidate as A beta plaque SPECT imaging agent for AD. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.026