1,3-dihydro-3-[2-(4-fluoro-3-methylphenyl)-2-oxo-ethylidene]-2H-indol-2-one thiosemicarbazone | 128316-85-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1,3-dihydro-3-[2-(4-fluoro-3-methylphenyl)-2-oxo-ethylidene]-2H-indol-2-one thiosemicarbazone
• 英文别名: 3-(4'-fluoro-3'-methyl)benzoyl-2-thiosemicarbazonomethyleneindolinon-2-one
• CAS: 128316-85-8
• 化学式: C₁₈H₁₅FN₄OS
• 分子量: 354.408
• InChiKey: WFPDOAPMDHBSJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.71
• 重原子数：
  25.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  79.51
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  indole-2,3-dione 3-thiosemicarbazone 、 二苯二氯硅烷 、 1,3-dihydro-3-[2-(4-fluoro-3-methylphenyl)-2-oxo-ethylidene]-2H-indol-2-one thiosemicarbazone 在 甲醇 、 sodium 作用下， 以73%的产率得到
  参考文献：
  名称：

  Coordination Behavior of Unsymmetrical Ligand Complexes of Diorganotin and Diorganosilicon Derived From Schiff Bases

  摘要：

  Hexacoordinated organotin and organosilicon derivatives have been prepared and characterized by analytical and spectroscopic techniques including UV, IR, H-1 NMR, and C-13 NMR spectra. The ligands used in the present account were derived by the condensation of thiosemicarbazide and 1H-Indol-2,3-dione, 1,3-dihydro-3-[2-(4-fluorophenyl)-2-oxo-ethylidene]-2H-indol-2-one, and 1,3-dihydro-3-[2-(4-fluoro3-methyl-phenyl)-2-oxo-ethylidene]-2H-indol-2-one under microwave irradiation as well as by conventional heating. Newly synthesized complexes with their corresponding ligands were tested for their antifungal and antibacterial activities. The aim of the present study is to synthesize some novel ecofriendly fungicides and bactericides that have important pharmacodynamic significance.

  DOI：

  10.1080/10426500601087384
• 作为产物：
  描述：

  1,3-dihydro-3-[2-(4-fluoro-3-methylphenyl)-2-oxo-ethylidene]-2H-indol-2-one 、 氨基硫脲 以 乙醇 为溶剂， 反应 0.75h， 以68%的产率得到1,3-dihydro-3-[2-(4-fluoro-3-methylphenyl)-2-oxo-ethylidene]-2H-indol-2-one thiosemicarbazone
  参考文献：
  名称：

  Coordination Behavior of Unsymmetrical Ligand Complexes of Diorganotin and Diorganosilicon Derived From Schiff Bases

  摘要：

  Hexacoordinated organotin and organosilicon derivatives have been prepared and characterized by analytical and spectroscopic techniques including UV, IR, H-1 NMR, and C-13 NMR spectra. The ligands used in the present account were derived by the condensation of thiosemicarbazide and 1H-Indol-2,3-dione, 1,3-dihydro-3-[2-(4-fluorophenyl)-2-oxo-ethylidene]-2H-indol-2-one, and 1,3-dihydro-3-[2-(4-fluoro3-methyl-phenyl)-2-oxo-ethylidene]-2H-indol-2-one under microwave irradiation as well as by conventional heating. Newly synthesized complexes with their corresponding ligands were tested for their antifungal and antibacterial activities. The aim of the present study is to synthesize some novel ecofriendly fungicides and bactericides that have important pharmacodynamic significance.

  DOI：

  10.1080/10426500601087384

文献信息

• Joshi, Krishna C.; Jain, Renuka, Heterocycles, 1990, vol. 31, # 3, p. 473 - 477
  作者：Joshi, Krishna C.、Jain, Renuka

  DOI：——

  日期：——