4-己基-1H-吡唑 | 73123-47-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-己基-1H-吡唑
• 英文名称: 4-Hexylpyrazol
• 英文别名: 4-hexyl-1H-pyrazole；4-Hexyl-1H-pyrazole
• CAS: 73123-47-4
• 化学式: C₉H₁₆N₂
• 分子量: 152.239
• InChiKey: RRESKZSKNBZJEF-UHFFFAOYSA-N

物化性质

• 沸点：
  270.7±9.0 °C(Predicted)
• 密度：
  0.952±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933199090
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

文献信息

• Specifically targeted catalytic antagonists and uses thereof
  申请人：——

  公开号：US20040170618A1

  公开（公告）日：2004-09-02

  This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.

  这项发明提供了催化拮抗剂的嵌合分子，该催化拮抗剂是目标分子的催化拮抗剂。该发明的催化拮抗剂优选包括连接到降解与靶向基团特异结合的酶的靶向基团。因此，该发明的催化拮抗剂结合到被靶向基团识别的目标（例如，受体），然后嵌合体的酶组分降解目标的全部或部分。这通常导致目标的活性减少或丧失，并释放出嵌合分子。然后，嵌合分子可以自由攻击和降解另一个目标分子。
• SPECIFICALLY TARGETED CATALYTIC ANTAGONISTS AND USES THEREOF
  申请人：Davis Benjamin G.

  公开号：US20110262419A1

  公开（公告）日：2011-10-27

  This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.

  本发明提供了嵌合分子，其是目标分子的催化拮抗剂。本发明的催化拮抗剂优选包含一个定向基团和一个酶，该酶特异性降解定向基团所结合的分子。本发明的催化拮抗剂因此结合到定向基团识别的目标上（例如受体），嵌合体的酶组分然后降解目标的全部或部分。这通常导致目标的活性降低或丧失，并释放嵌合分子。然后嵌合分子就可以自由攻击和降解另一个目标分子。
• METHOD AND PRODUCTS FOR THE SELECTIVE DEGRADATION OF PROTEINS
  申请人：UNIVERSITY OF LEEDS

  公开号：EP1730289A2

  公开（公告）日：2006-12-13
• Method and Products For the Selective Degradation of Proteins
  申请人：Colyer John

  公开号：US20080139467A1

  公开（公告）日：2008-06-12

  The present invention provides a method of controlling levels/concentrations of a target moiety. The method of the present invention includes introducing into a cell a product comprising at least one of each of the following modules: a targeting module, a destruction module and a replacement module. The method further comprises targeting the target moiety with the targeting module so that the destruction module can effect degradation of the target moiety and replacing the target moiety with a replacement: module. The replacement module may be either a modified form of the target moiety itself or a functional unit which restores normal metabolic activity of the cell. The present invention also a destruction module and a replacement module, nucleic acids encoding the products and vectors. The present invention also provides for use of the method and products in treating various clinical disorders.
• US8431121B2
  申请人：——

  公开号：US8431121B2

  公开（公告）日：2013-04-30