5-Methoxy-8-(3-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine | 511541-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Methoxy-8-(3-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine
• 英文别名: 5-Methoxy-8-(3-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
• CAS: 511541-45-0
• 化学式: C₁₄H₁₄N₄O₂
• 分子量: 270.291
• InChiKey: CBLFFQIHOVTWIF-UHFFFAOYSA-N

物化性质

• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Adenosine receptor ligands
  申请人：——

  公开号：US20030134873A1

  公开（公告）日：2003-07-17

  The present application relates to compounds of the formula 1 wherein R 1 is hydrogen, halogen or lower alkoxy; R 2 is hydrogen or is —C(O)-lower alkyl or —C(O)-phenyl, wherein the phenyl ring is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy and trifluoromethyl, or is —C(O)-furanyl or —C(O)-thiophenyl, wherein the rings are unsubstituted or substituted by halogen; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases associated with the adenosine A 2 receptor.

  本申请涉及以下式1的化合物，其中R1为氢、卤素或较低的烷氧基；R2为氢，或者为—C(O)-较低烷基或—C(O)-苯基，其中苯环未取代或取代为来自卤素、较低烷基、较低烷氧基和三氟甲基的一种或两种取代基，或者为—C(O)-呋喃基或—C(O)-噻吩基，其中环未取代或取代为卤素；或其药学上可接受的盐。这些化合物在治疗与腺苷A2受体相关的疾病中有用。
• 5-METHOXY-8-ARYL-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1436292A1

  公开（公告）日：2004-07-14
• 5-METHOXY-8-ARYL-¬1,2,4|TRIAZOLO¬1,5-A|PYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1436292B1

  公开（公告）日：2006-08-30
• US6693116B2
  申请人：——

  公开号：US6693116B2

  公开（公告）日：2004-02-17
• [EN] 5-METHOXY-8-ARYL-[1,2,4] TRIAZOLO [1,5-A] PYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE 5-METHOXY-8-ARYL-[1,2,4] TRIAZOLO [1,5-A] PYRIDINE EN TANT QU'ANTAGONISTES DU RECEPTEUR D'ADENOSINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003031445A1

  公开（公告）日：2003-04-17

  The present application relates to compounds of the formula (I) wherein R1 is hydrogen, halogen or lower alkoxy; R2 is hydrogen or is C(O)- lower alkyl or -C(0)-phenyl, wherein the phenyl ring is unsubstituted or substituted by one or two substituents, selected from the group, consisting of halogen, lower alkoxy or trifluoromethyl, or is -C(O)-furanyl or -C(O)- thiophenyl, wherein the rings are unsubstituted or substituted by halogen; and to their pharmaceutically acceptable salts. The compounds may be used in the treatment of diseases associated with the adenosine A2 receptor.